Divalent Metal Transporter 1 (DMT1) ELISA Kit for Human

Name: Human DMT1 ELISA Kit; Divalent Metal Transporter 1; MyBioSource
Brand: MyBioSource
SKU: MBS456116
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS456116

MBS456116 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Divalent Metal Transporter 1 (DMT1) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

$520 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Divalent Metal Transporter 1 (DMT1), ELISA Kit

Full Product Name

Human Divalent Metal Transporter 1 (DMT1) ELISA Kit

Product Gene Name

DMT1 elisa kit

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue homogenates, cell lysates and other biological fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.112ng/mL

Preparation and Storage

For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Molecular Weight

61,048 Da

OMIM

AB004857 mRNA

3D Structure

ModBase 3D Structure for P49281

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of DMT1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DMT1. It may not necessarily be applicable to this product.

NCBI GI #

10835169

NCBI GeneID

4891

NCBI Accession #

NP_000608.1

UniProt Primary Accession #

P49281

UniProt Secondary Accession #

O43288; O60932; O94801; Q498Z5; Q8IUD7; Q96J35; B3KT08; B4DK84; F5H741

UniProt Related Accession #

P49281

GenBank Nucleotide #

NM_000617.2

NCBI Official Full Name

natural resistance-associated macrophage protein 2 isoform 3

NCBI Official Synonym Full Names

solute carrier family 11 member 2

NCBI Official Symbol

SLC11A2

NCBI Official Synonym Symbols

DCT1; DMT1; AHMIO1; NRAMP2

UniProt Protein Name

Natural resistance-associated macrophage protein 2

UniProt Synonym Protein Names

Divalent cation transporter 1; Divalent metal transporter 1; DMT-1; Solute carrier family 11 member 2

UniProt Gene Name

SLC11A2

UniProt Synonym Gene Names

DCT1; DMT1; NRAMP2; NRAMP 2; DMT-1

NCBI Protein Information

natural resistance-associated macrophage protein 2

NCBI Summary for DMT1

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

UniProt Comments for DMT1

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.

Research Articles on DMT1

1. Gene silencing of either CTR1 or DMT1 did not affect copper accumulation in cells, but deficiency in both CTR1 and DMT1 resulted in a complete inhibition of copper uptake.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DMT1 elisa kit

Reference Product	PubMed Publications
SLC40A1 elisa kit	>9 publications with DMT1 and SLC40A1
TFRC elisa kit	>8 publications with DMT1 and TFRC
HAMP elisa kit	>6 publications with DMT1 and HAMP
CYBRD1 elisa kit	>4 publications with DMT1 and CYBRD1
HEPH elisa kit	>3 publications with DMT1 and HEPH
EPAS1 elisa kit	>2 publications with DMT1 and EPAS1

Pathways associated with DMT1 elisa kit

Products by Pathway	Pathway Diagram
Copper Homeostasis Pathway antibodies	Copper Homeostasis Pathway Diagram
HIF-2-alpha Transcription Factor Network Pathway antibodies	HIF-2-alpha Transcription Factor Network Pathway Diagram
Iron Metabolism In Placenta Pathway antibodies	Iron Metabolism In Placenta Pathway Diagram
Iron Uptake And Transport Pathway antibodies	Iron Uptake And Transport Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Metal Ion SLC Transporters Pathway antibodies	Metal Ion SLC Transporters Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
Mineral Absorption Pathway antibodies	Mineral Absorption Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram

Diseases associated with DMT1 elisa kit

Disease Name	Pubmed Publications
Anemia Antibodies	>29 publications with DMT1 and Anemia
Anemia, Iron-Deficiency Antibodies	>14 publications with DMT1 and Anemia, Iron-Deficiency
Brain Diseases Antibodies	>9 publications with DMT1 and Brain Diseases
Hemochromatosis Antibodies	>9 publications with DMT1 and Hemochromatosis
Nervous System Diseases Antibodies	>8 publications with DMT1 and Nervous System Diseases
Disease Models, Animal Antibodies	>6 publications with DMT1 and Disease Models, Animal
Kidney Diseases Antibodies	>3 publications with DMT1 and Kidney Diseases
Weight Loss Antibodies	>2 publications with DMT1 and Weight Loss
Fibrosis Antibodies	>2 publications with DMT1 and Fibrosis
Liver Diseases Antibodies	>2 publications with DMT1 and Liver Diseases

Organs/Tissues associated with DMT1 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>25 publications with DMT1 and Blood
Intestine Antibodies	>18 publications with DMT1 and Intestine
Liver Antibodies	>17 publications with DMT1 and Liver
Kidney Antibodies	>13 publications with DMT1 and Kidney
Brain Antibodies	>11 publications with DMT1 and Brain
Lung Antibodies	>3 publications with DMT1 and Lung
Placenta Antibodies	>3 publications with DMT1 and Placenta
Bone Antibodies	>3 publications with DMT1 and Bone
Spleen Antibodies	>2 publications with DMT1 and Spleen
Ovary Antibodies	>2 publications with DMT1 and Ovary