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Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS456849

Intended Uses: The kit is a sandwich enzyme immunoassay for the in vitro quantitative measurement of CYSLTR2 in human tissue homogenates and other biological fluids.Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Cysteinyl Leukotriene Receptor 2 (CYSLTR2), ELISA Kit
Full Product Name
Human Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit
Product Gene Name
CYSLTR2 elisa kit
Product Synonym Names
CYSLT2; GPCR; CYSLT2R; HG57; HPN321; HGPCR21; G-protein coupled receptor GPCR21; G-protein coupled receptor HG57
Species Reactivity
Human
Assay Type
Quantitative Sandwich
Samples
Tissue homogenates and other biological fluids
Detection Range
0.312-20ng/mL
Sensitivity
<0.108ng/mL.
Specificity
This assay has high sensitivity and excellent specificity for detection of CYSLTR2. No significant cross-reactivity or interference between CYSLTR2 and analogues was observed.
Inter-assay Precision
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level CYSLTR2 were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100. Inter-Assay: CV<12%
Intra-assay Precision
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level CYSLTR2 were tested 20 times on one plate, respectively. Intra-Assay: CV<10%
Molecular Weight
39,635 Da
OMIM
AB038269 mRNA
3D Structure
ModBase 3D Structure for Q9NS75
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of CYSLTR2 elisa kit

Human CYSLTR2 ELISA Kit – Cat# MBS456849

Other Notes

Small volumes of CYSLTR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYSLTR2 purchase

MBS456849 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cysteinyl Leukotriene Receptor 2 (CYSLTR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CYSLTR2. The ELISA analytical biochemical technique of the MBS456849 kit is based on CYSLTR2 antibody-CYSLTR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYSLTR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYSLTR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CYSLTR2. It may not necessarily be applicable to this product.

NCBI GI #
818213437
NCBI GeneID
57105
NCBI Accession #
NP_001295394.1
UniProt Primary Accession #
Q9NS75
UniProt Secondary Accession #
Q9HCQ2
UniProt Related Accession #
Q9NS75
GenBank Nucleotide #
NM_001308465.2
NCBI Official Full Name
cysteinyl leukotriene receptor 2
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 2
NCBI Official Symbol
CYSLTR2
NCBI Official Synonym Symbols
HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
UniProt Protein Name
Cysteinyl leukotriene receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321
Protein Family
Cysteinyl leukotriene receptor
UniProt Gene Name
CYSLTR2
UniProt Synonym Gene Names
CYSLT2; CYSLT2R; CysLTR2; hGPCR21
NCBI Protein Information
cysteinyl leukotriene receptor 2

NCBI Summary for CYSLTR2

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYSLTR2

CYSLTR2: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: cysteinyl leukotriene receptor activity; leukotriene receptor activity; peptide receptor activity, G-protein coupled; protein binding

Biological Process: immune response; neuropeptide signaling pathway; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of angiogenesis
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Research Articles on CYSLTR2

1. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CYSLTR2 elisa kit

 Reference Product  PubMed Publications
 CYSLTR1 elisa kit  >23 publications with CYSLTR2 and CYSLTR1
 TBXA2R elisa kit  >3 publications with CYSLTR2 and TBXA2R
 GPR17 elisa kit  >2 publications with CYSLTR2 and GPR17
 LTB4R2 elisa kit  >1 publications with CYSLTR2 and LTB4R2

Pathways associated with CYSLTR2 elisa kit

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with CYSLTR2 elisa kit

 Disease Name  Pubmed Publications
 Asthma Antibodies  >21 publications with CYSLTR2 and Asthma
 Lung Diseases, Obstructive Antibodies  >16 publications with CYSLTR2 and Lung Diseases, Obstructive
 Inflammation Antibodies  >10 publications with CYSLTR2 and Inflammation
 Uveal melanoma Antibodies  >5 publications with CYSLTR2 and Uveal melanoma
 Asthma, Aspirin-Induced Antibodies  >4 publications with CYSLTR2 and Asthma, Aspirin-Induced
 Drug Hypersensitivity Antibodies  >3 publications with CYSLTR2 and Drug Hypersensitivity
 Necrosis Antibodies  >2 publications with CYSLTR2 and Necrosis
 Hyperplasia Antibodies  >2 publications with CYSLTR2 and Hyperplasia
 Pain Antibodies  >2 publications with CYSLTR2 and Pain
 Carcinoma Antibodies  >1 publications with CYSLTR2 and Carcinoma

Organs/Tissues associated with CYSLTR2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with CYSLTR2 and Placenta
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