Calcium Channel, Voltage Dependent, R-Type, Alpha 1e Subunit () ELISA Kit for Mouse

Name: Mouse ELISA Kit; Calcium Channel, Voltage Dependent, R-Type, Alpha 1e Subunit (); MyBioSource
Brand: MyBioSource
SKU: MBS458072
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS458072

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to CACNa1E. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to… More details

$550 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E), ELISA Kit

Full Product Name

Mouse Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) ELISA Kit

Product Gene Name

CACNa1E elisa kit

Product Synonym Names

BII; CACNL1A6; CACH6; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3

Species Reactivity

Mouse

Assay Type

Sandwich

Samples

Tissue Homogenates, Cell Lysates or Other Biological Fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.121ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

257,236 Da

3D Structure

ModBase 3D Structure for Q61290

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of CACNa1E elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNa1E purchase

MBS458072 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNa1E. The ELISA analytical biochemical technique of the MBS458072 kit is based on CACNa1E antibody-CACNa1E antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNa1E antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNa1E. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CACNa1E. It may not necessarily be applicable to this product.

NCBI GI #

5921699

NCBI GeneID

12290

NCBI Accession #

Q61290.1

UniProt Primary Accession #

Q61290

UniProt Related Accession #

Q61290

NCBI Official Full Name

Voltage-dependent R-type calcium channel subunit alpha-1E

NCBI Official Synonym Full Names

calcium channel, voltage-dependent, R type, alpha 1E subunit

NCBI Official Symbol

Cacna1e

NCBI Official Synonym Symbols

BII; Cach6; Cav2.3; Cchra1; alpha1E; Cacnl1a6; A430040I15

UniProt Protein Name

Voltage-dependent R-type calcium channel subunit alpha-1E

UniProt Synonym Protein Names

Brain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3

Protein Family

Voltage-dependent R-type calcium channel

UniProt Gene Name

Cacna1e

UniProt Synonym Gene Names

Cach6; Cacnl1a6; Cchra1; BII

NCBI Protein Information

voltage-dependent R-type calcium channel subunit alpha-1E

NCBI Summary for CACNa1E

This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]

UniProt Comments for CACNa1E

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Research Articles on CACNa1E

1. The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR-34c-5p.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CACNa1E elisa kit

Reference Product	PubMed Publications
Cacnb2 elisa kit	>4 publications with CACNa1E and Cacnb2
Cacna1c elisa kit	>2 publications with CACNa1E and Cacna1c
Cacnb3 elisa kit	>2 publications with CACNa1E and Cacnb3
Cacnb1 elisa kit	>2 publications with CACNa1E and Cacnb1
Cacnb4 elisa kit	>2 publications with CACNa1E and Cacnb4

Pathways associated with CACNa1E elisa kit

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies	Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
Integration Of Energy Metabolism Pathway antibodies	Integration Of Energy Metabolism Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Regulation Of Insulin Secretion Pathway antibodies	Regulation Of Insulin Secretion Pathway Diagram

Organs/Tissues associated with CACNa1E elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>43 publications with CACNa1E and Brain
Kidney Antibodies	>13 publications with CACNa1E and Kidney
Heart Antibodies	>8 publications with CACNa1E and Heart
Eye Antibodies	>6 publications with CACNa1E and Eye
Sympathetic Ganglion Antibodies	>1 publications with CACNa1E and Sympathetic Ganglion