Calcium Sensing Receptor (CASR) ELISA Kit for Mouse

Name: Mouse CASR ELISA Kit; Calcium Sensing Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS458140
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS458140

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to CASR. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to CASR.… More details

$550 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Calcium Sensing Receptor (CASR), ELISA Kit

Full Product Name

Mouse Calcium Sensing Receptor (CASR) ELISA Kit

Product Gene Name

CASR elisa kit

Product Synonym Names

CAR; FHH; FIH; GPRC2A; HHC; HHC1; NSHPT; PCAR1; Parathyroid cell calcium-sensing receptor 1; Hypocalciuric Hypercalcemia 1; Severe Neonatal Hyperparathyroidism

Species Reactivity

Mouse

Assay Type

Sandwich

Samples

Tissue Homogenates, Cell Lysates or Other Biological Fluids.

Detection Range

0.156-10ng/mL

Sensitivity

0.057ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

111,996 Da

3D Structure

ModBase 3D Structure for Q9QY96

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of CASR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASR purchase

MBS458140 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Calcium Sensing Receptor (CASR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CASR. The ELISA analytical biochemical technique of the MBS458140 kit is based on CASR antibody-CASR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.

NCBI GI #

148762954

NCBI GeneID

12374

NCBI Accession #

NP_038831.2

UniProt Primary Accession #

Q9QY96

UniProt Secondary Accession #

O08968; O88519; Q9QY95; Q9QZU8; Q9R1D6; Q9R1Y2; G3UX06

UniProt Related Accession #

Q9QY96

GenBank Nucleotide #

NM_013803.3

NCBI Official Full Name

extracellular calcium-sensing receptor

NCBI Official Synonym Full Names

calcium-sensing receptor

NCBI Official Symbol

Casr

NCBI Official Synonym Symbols

CaR; Gprc2a

UniProt Protein Name

Extracellular calcium-sensing receptor

UniProt Synonym Protein Names

Parathyroid cell calcium-sensing receptor; PCaR1

Protein Family

Extracellular calcium-sensing receptor

UniProt Gene Name

Casr

UniProt Synonym Gene Names

CaSR; PCaR1

NCBI Protein Information

extracellular calcium-sensing receptor

UniProt Comments for CASR

G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (PubMed:7493018). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation ().

Research Articles on CASR

1. These findings indicate that cardiac function could be enhanced significantly by combination therapy with CaSR inhibition and ESC transplantation; the effect was better than ESC transplantation alone, and the mechanism might be associated with a reduction in cell apoptosis via the inhibition of the MAPK pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CASR elisa kit

Reference Product	PubMed Publications
App elisa kit	>3 publications with CASR and App
Rgs4 elisa kit	>2 publications with CASR and Rgs4
Npsr1 elisa kit	>1 publications with CASR and Npsr1

Pathways associated with CASR elisa kit

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram

Diseases associated with CASR elisa kit

Disease Name	Pubmed Publications
Hyperparathyroidism Antibodies	>276 publications with CASR and Hyperparathyroidism
Hypercalcemia Antibodies	>235 publications with CASR and Hypercalcemia
Hypocalcemia Antibodies	>148 publications with CASR and Hypocalcemia
Kidney Diseases Antibodies	>116 publications with CASR and Kidney Diseases
Hypoparathyroidism Antibodies	>91 publications with CASR and Hypoparathyroidism
Hypertension Antibodies	>60 publications with CASR and Hypertension
Cardiovascular Diseases Antibodies	>60 publications with CASR and Cardiovascular Diseases
Inflammation Antibodies	>41 publications with CASR and Inflammation
Hyperplasia Antibodies	>39 publications with CASR and Hyperplasia
Hypocalciuric hypercalcemia, familial, type 1 Antibodies	>35 publications with CASR and Hypocalciuric hypercalcemia, familial, type 1

Organs/Tissues associated with CASR elisa kit

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>281 publications with CASR and Kidney
Pancreas Antibodies	>22 publications with CASR and Pancreas
Mixed Antibodies	>8 publications with CASR and Mixed
Testis Antibodies	>4 publications with CASR and Testis