Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit for Human

Name: Human CYR61 ELISA Kit; Cysteine Rich Protein, Angiogenic Inducer 61; MyBioSource
Brand: MyBioSource
SKU: MBS458756
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS458756

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to CYR61. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to CYR61.… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61), ELISA Kit

Full Product Name

Human Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit

Product Gene Name

CYR61 elisa kit

Product Synonym Names

CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Tissue Homogenates, Cell Lysates or Other Biological Fluids.

Detection Range

31.2-2000pg/mL

Sensitivity

13.4pg/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

42,027 Da

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of CYR61 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYR61 purchase

MBS458756 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CYR61. The ELISA analytical biochemical technique of the MBS458756 kit is based on CYR61 antibody-CYR61 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYR61 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYR61. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.

NCBI GI #

31542331

NCBI GeneID

3491

NCBI Accession #

NP_001545.2

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622

GenBank Nucleotide #

NM_001554.4

NCBI Official Full Name

protein CYR61

NCBI Official Synonym Full Names

cysteine rich angiogenic inducer 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

Protein

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

NCBI Protein Information

protein CYR61

NCBI Summary for CYR61

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

UniProt Comments for CYR61

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Research Articles on CYR61

1. CCN1 stimulates CCL20 production in vitro and in vivo, and thus supports the notion that overexpressed CCN1 in hyperproliferating keratinocyte is functionally involved in the recruitment of inflammatory cells to skin lesions affected by psoriasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CYR61 elisa kit

Reference Product	PubMed Publications
JUN elisa kit	>85 publications with CYR61 and JUN
FOS elisa kit	>19 publications with CYR61 and FOS
CTNNB1 elisa kit	>14 publications with CYR61 and CTNNB1
SRF elisa kit	>5 publications with CYR61 and SRF
MKL1 elisa kit	>4 publications with CYR61 and MKL1
ITGB2 elisa kit	>1 publications with CYR61 and ITGB2
ITGAV elisa kit	>1 publications with CYR61 and ITGAV

Pathways associated with CYR61 elisa kit

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with CYR61 elisa kit

Disease Name	Pubmed Publications
Carcinoma Antibodies	>83 publications with CYR61 and Carcinoma
Inflammation Antibodies	>51 publications with CYR61 and Inflammation
Disease Models, Animal Antibodies	>45 publications with CYR61 and Disease Models, Animal
Breast Neoplasms Antibodies	>40 publications with CYR61 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>40 publications with CYR61 and Neoplasm Metastasis
Fibrosis Antibodies	>37 publications with CYR61 and Fibrosis
Nervous System Diseases Antibodies	>29 publications with CYR61 and Nervous System Diseases
Necrosis Antibodies	>25 publications with CYR61 and Necrosis
Neoplasms, Experimental Antibodies	>23 publications with CYR61 and Neoplasms, Experimental
Brain Diseases Antibodies	>22 publications with CYR61 and Brain Diseases

Organs/Tissues associated with CYR61 elisa kit

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>179 publications with CYR61 and Connective Tissue
Vascular Antibodies	>127 publications with CYR61 and Vascular
Bone Antibodies	>77 publications with CYR61 and Bone
Muscle Antibodies	>76 publications with CYR61 and Muscle
Embryonic Tissue Antibodies	>53 publications with CYR61 and Embryonic Tissue
Lung Antibodies	>50 publications with CYR61 and Lung
Brain Antibodies	>38 publications with CYR61 and Brain
Prostate Antibodies	>31 publications with CYR61 and Prostate
Skin Antibodies	>29 publications with CYR61 and Skin
Kidney Antibodies	>27 publications with CYR61 and Kidney