Fibulin 5 (FBLN5) ELISA Kit for Human

Name: Human FBLN5 ELISA Kit; Fibulin 5; MyBioSource
Brand: MyBioSource
SKU: MBS459223
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459223

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FBLN5. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to FBLN5.… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Fibulin 5 (FBLN5), ELISA Kit

Full Product Name

Human Fibulin 5 (FBLN5) ELISA Kit

Product Gene Name

FBLN5 elisa kit

Product Synonym Names

ARMD3; DANCE; EVEC; UP50; FIBL-5; Dance; Developmental arteries and neural crest EGF-like protein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Urine or Other Biological Fluids.

Detection Range

3.12-200ng/mL

Sensitivity

1.24ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

50,180 Da

OMIM

219100

3D Structure

ModBase 3D Structure for Q9UBX5

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of FBLN5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBLN5 purchase

MBS459223 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fibulin 5 (FBLN5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FBLN5. The ELISA analytical biochemical technique of the MBS459223 kit is based on FBLN5 antibody-FBLN5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FBLN5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FBLN5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FBLN5. It may not necessarily be applicable to this product.

NCBI GI #

19743803

NCBI GeneID

10516

NCBI Accession #

NP_006320.2

UniProt Primary Accession #

Q9UBX5

UniProt Secondary Accession #

O75966; Q6IAL4; Q6UWA3

UniProt Related Accession #

Q9UBX5

GenBank Nucleotide #

NM_006329.3

NCBI Official Full Name

fibulin-5

NCBI Official Synonym Full Names

fibulin 5

NCBI Official Symbol

FBLN5

NCBI Official Synonym Symbols

EVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5; HNARMD

UniProt Protein Name

Fibulin-5

UniProt Synonym Protein Names

Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50

Protein Family

Fibulin

UniProt Gene Name

FBLN5

UniProt Synonym Gene Names

DANCE; FIBL-5; Dance; UP50

NCBI Protein Information

fibulin-5

NCBI Summary for FBLN5

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

UniProt Comments for FBLN5

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).

Research Articles on FBLN5

1. Serum fibulin-5 concentration can be regarded as a biomarker for evaluating disease severity and predicting prognosis in intracerebral hemorrhage patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FBLN5 elisa kit

Reference Product	PubMed Publications
LOXL1 elisa kit	>10 publications with FBLN5 and LOXL1
SOD3 elisa kit	>1 publications with FBLN5 and SOD3

Pathways associated with FBLN5 elisa kit

Products by Pathway	Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Molecules Associated With Elastic Fibres Pathway antibodies	Molecules Associated With Elastic Fibres Pathway Diagram

Diseases associated with FBLN5 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>21 publications with FBLN5 and Neoplasms
Cardiovascular Diseases Antibodies	>16 publications with FBLN5 and Cardiovascular Diseases
Vascular Diseases Antibodies	>11 publications with FBLN5 and Vascular Diseases
Heart Diseases Antibodies	>9 publications with FBLN5 and Heart Diseases
Emphysema Antibodies	>5 publications with FBLN5 and Emphysema
Nervous System Diseases Antibodies	>5 publications with FBLN5 and Nervous System Diseases
Lung Neoplasms Antibodies	>4 publications with FBLN5 and Lung Neoplasms
Inflammation Antibodies	>3 publications with FBLN5 and Inflammation
Macular Degeneration, Age-Related, 3 Antibodies	>2 publications with FBLN5 and Macular Degeneration, Age-Related, 3
CUTIS LAXA, AUTOSOMAL DOMINANT 1 Antibodies	>2 publications with FBLN5 and CUTIS LAXA, AUTOSOMAL DOMINANT 1

Organs/Tissues associated with FBLN5 elisa kit

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>52 publications with FBLN5 and Connective Tissue
Skin Antibodies	>39 publications with FBLN5 and Skin
Vascular Antibodies	>35 publications with FBLN5 and Vascular
Muscle Antibodies	>23 publications with FBLN5 and Muscle
Lung Antibodies	>18 publications with FBLN5 and Lung
Heart Antibodies	>10 publications with FBLN5 and Heart
Embryonic Tissue Antibodies	>9 publications with FBLN5 and Embryonic Tissue
Bone Antibodies	>7 publications with FBLN5 and Bone
Eye Antibodies	>6 publications with FBLN5 and Eye
Uterus Antibodies	>6 publications with FBLN5 and Uterus