Filamin B Beta (FLNb) ELISA Kit for Human

Name: Human FLNb ELISA Kit; Filamin B Beta; MyBioSource
Brand: MyBioSource
SKU: MBS459351
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459351

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FLNb. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to FLNb.… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Filamin B Beta (FLNb), ELISA Kit

Full Product Name

Human Filamin B Beta (FLNb) ELISA Kit

Product Gene Name

FLNb elisa kit

Product Synonym Names

ABP-278; AOI; FH1; FLN1L; LRS1; SCT; TABP; TAP; Actin Binding Protein 278; Actin-binding-like protein; Thyroid autoantigen; Filamin-3; Truncated actin-binding protein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue Homogenates, Cell Lysates or Other Biological Fluids.

Detection Range

15.6-1000pg/mL

Sensitivity

5.4pg/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

276,939 Da

OMIM

108720

3D Structure

ModBase 3D Structure for O75369

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of FLNb elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLNb purchase

MBS459351 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin B Beta (FLNb) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLNb. The ELISA analytical biochemical technique of the MBS459351 kit is based on FLNb antibody-FLNb antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLNb antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLNb. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FLNb. It may not necessarily be applicable to this product.

NCBI GI #

256222411

NCBI GeneID

2317

NCBI Accession #

NP_001157789.1

UniProt Primary Accession #

O75369

UniProt Secondary Accession #

Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4

UniProt Related Accession #

O75369

GenBank Nucleotide #

NM_001164317.1

NCBI Official Full Name

filamin-B isoform 1

NCBI Official Synonym Full Names

filamin B

NCBI Official Symbol

FLNB

NCBI Official Synonym Symbols

AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280

UniProt Protein Name

Filamin-B

UniProt Synonym Protein Names

ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP

Protein Family

Filamin

UniProt Gene Name

FLNB

UniProt Synonym Gene Names

FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP

NCBI Protein Information

filamin-B

NCBI Summary for FLNb

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

UniProt Comments for FLNb

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

Research Articles on FLNb

1. We report the case of a male patient with Larsen syndrome found to be mosaic for a novel point mutation in FLNB in whom it was possible to provide evidence-based personalized counseling on transmission risk to future offspring. Using dideoxy sequencing, a low-level FLNB c.698A>G, encoding p.(Tyr233Cys) mutation was detected in buccal mucosa and fibroblast DNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FLNb elisa kit

Products by Pathway	Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram

Diseases associated with FLNb elisa kit

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>19 publications with FLNb and Congenital Abnormalities
Spondylocarpotarsal synostosis Antibodies	>7 publications with FLNb and Spondylocarpotarsal synostosis
Boomerang dysplasia Antibodies	>6 publications with FLNb and Boomerang dysplasia
Nervous System Diseases Antibodies	>4 publications with FLNb and Nervous System Diseases
Liver Neoplasms Antibodies	>3 publications with FLNb and Liver Neoplasms
Liver Diseases Antibodies	>3 publications with FLNb and Liver Diseases
Adenocarcinoma Antibodies	>3 publications with FLNb and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>3 publications with FLNb and Carcinoma, Hepatocellular
Cardiovascular Diseases Antibodies	>2 publications with FLNb and Cardiovascular Diseases
ATELOSTEOGENESIS, TYPE III Antibodies	>2 publications with FLNb and ATELOSTEOGENESIS, TYPE III

Organs/Tissues associated with FLNb elisa kit

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>20 publications with FLNb and Bone
Connective Tissue Antibodies	>7 publications with FLNb and Connective Tissue
Heart Antibodies	>4 publications with FLNb and Heart
Blood Antibodies	>4 publications with FLNb and Blood
Vascular Antibodies	>4 publications with FLNb and Vascular
Brain Antibodies	>4 publications with FLNb and Brain
Nerve Antibodies	>3 publications with FLNb and Nerve
Muscle Antibodies	>3 publications with FLNb and Muscle
Liver Antibodies	>3 publications with FLNb and Liver
Embryonic Tissue Antibodies	>2 publications with FLNb and Embryonic Tissue