Filamin C Gamma (FLNC) ELISA Kit for Human

Name: Human FLNC ELISA Kit; Filamin C Gamma; MyBioSource
Brand: MyBioSource
SKU: MBS459352
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459352

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to FLNC. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to FLNC.… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Filamin C Gamma (FLNC), ELISA Kit

Full Product Name

Human Filamin C Gamma (FLNC) ELISA Kit

Product Gene Name

FLNC elisa kit

Product Synonym Names

ABP-280; ABP280A; ABPA; ABPL; FLN2; Actin Binding Protein 280; ABP-280-like protein; Actin-binding-like protein; Filamin-2

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates or Other Biological Fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.126ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

287,281 Da

OMIM

102565

3D Structure

ModBase 3D Structure for Q14315

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of FLNC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLNC purchase

MBS459352 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin C Gamma (FLNC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLNC. The ELISA analytical biochemical technique of the MBS459352 kit is based on FLNC antibody-FLNC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLNC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLNC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FLNC. It may not necessarily be applicable to this product.

NCBI GI #

188595687

NCBI GeneID

2318

NCBI Accession #

NP_001120959.1

UniProt Primary Accession #

Q14315

UniProt Secondary Accession #

O95303; Q07985; Q9NS12; Q9NYE5; Q9UMR8; Q9Y503; B2ZZ88

UniProt Related Accession #

Q14315

GenBank Nucleotide #

NM_001127487.1

NCBI Official Full Name

filamin-C isoform b

NCBI Official Synonym Full Names

filamin C

NCBI Official Symbol

FLNC

NCBI Official Synonym Symbols

ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A

UniProt Protein Name

Filamin-C

UniProt Synonym Protein Names

ABP-280-like protein; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin

Protein Family

Filamin

UniProt Gene Name

FLNC

UniProt Synonym Gene Names

ABPL; FLN2; FLN-C; FLNc

NCBI Protein Information

filamin-C

NCBI Summary for FLNC

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for FLNC

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

Research Articles on FLNC

1. Study found a novel splice-site mutation in FLNC gene (c.2389+1G>A) which co-segregated with all symptomatic individuals in the family with dilated cardiomyopathy (DCM). These results strongly suggest that the involvement of FLNC gene, due to haploinsufficiency, should be considered in familial cases with DCM, especially if accompanied with arrhythmia and increased incidence of sudden cardiac death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FLNC elisa kit

Reference Product	PubMed Publications
MAP2K4 elisa kit	>2 publications with FLNC and MAP2K4
PSEN1 elisa kit	>1 publications with FLNC and PSEN1

Pathways associated with FLNC elisa kit

Products by Pathway	Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-extracellular Matrix Interactions Pathway antibodies	Cell-extracellular Matrix Interactions Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with FLNC elisa kit

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>13 publications with FLNC and Heart Diseases
Cardiovascular Diseases Antibodies	>13 publications with FLNC and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>8 publications with FLNC and Congenital Abnormalities
Hypertrophy Antibodies	>5 publications with FLNC and Hypertrophy
Filaminopathy, autosomal dominant Antibodies	>5 publications with FLNC and Filaminopathy, autosomal dominant
Neoplasms, Experimental Antibodies	>3 publications with FLNC and Neoplasms, Experimental
Inflammation Antibodies	>3 publications with FLNC and Inflammation
Disease Models, Animal Antibodies	>2 publications with FLNC and Disease Models, Animal
Ovarian Diseases Antibodies	>2 publications with FLNC and Ovarian Diseases
Fibrosis Antibodies	>2 publications with FLNC and Fibrosis

Organs/Tissues associated with FLNC elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>70 publications with FLNC and Muscle
Heart Antibodies	>18 publications with FLNC and Heart
Blood Antibodies	>13 publications with FLNC and Blood
Brain Antibodies	>10 publications with FLNC and Brain
Stomach Antibodies	>10 publications with FLNC and Stomach
Vascular Antibodies	>9 publications with FLNC and Vascular
Nerve Antibodies	>8 publications with FLNC and Nerve
Liver Antibodies	>4 publications with FLNC and Liver
Prostate Antibodies	>4 publications with FLNC and Prostate
Bone Antibodies	>3 publications with FLNC and Bone