Growth Hormone Receptor (GHR) ELISA Kit for Human

Name: Human GHR ELISA Kit; Growth Hormone Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS459575
Price: 525 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459575

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to GHR. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to GHR. Next,… More details

$525 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Growth Hormone Receptor (GHR), ELISA Kit

Full Product Name

Human Growth Hormone Receptor (GHR) ELISA Kit

Product Gene Name

GHR elisa kit

Product Synonym Names

GHBP; Somatotropin receptor; Growth hormone-binding protein; Serum-binding protein

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue Homogenates, Cell Lysates or Other Biological Fluids.

Detection Range

1.56-100ng/mL

Sensitivity

0.62ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

69,237 Da

OMIM

143890

3D Structure

ModBase 3D Structure for P10912

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of GHR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GHR purchase

MBS459575 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Hormone Receptor (GHR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GHR. The ELISA analytical biochemical technique of the MBS459575 kit is based on GHR antibody-GHR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GHR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GHR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GHR. It may not necessarily be applicable to this product.

NCBI GI #

4503993

NCBI GeneID

2690

NCBI Accession #

NP_000154.1

UniProt Primary Accession #

P10912

UniProt Secondary Accession #

Q9HCX2

UniProt Related Accession #

P10912

GenBank Nucleotide #

NM_000163.4

NCBI Official Full Name

growth hormone receptor isoform 1

NCBI Official Synonym Full Names

growth hormone receptor

NCBI Official Symbol

GHR

NCBI Official Synonym Symbols

GHBP; GHIP

UniProt Protein Name

Growth hormone receptor

UniProt Synonym Protein Names

Somatotropin receptor

Protein Family

Growth hormone receptor

UniProt Gene Name

GHR

UniProt Synonym Gene Names

GH receptor; GH-binding protein; GHBP

NCBI Protein Information

growth hormone receptor

NCBI Summary for GHR

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

UniProt Comments for GHR

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway ().

Research Articles on GHR

1. In a meta-analysis of a combined group of 324 acromegaly patients obtained from 4 separate study cohorts, the presence of 1 or 2 copies of the exon 3 deletion-GHR polymorphism had no significant effect on the lowest insulin-like growth factor I levels during pegvisomant treatment nor on the required pegvisomant dose to achieve these levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GHR elisa kit

Reference Product	PubMed Publications
JAK2 elisa kit	>170 publications with GHR and JAK2
STAT5B elisa kit	>60 publications with GHR and STAT5B
PRL elisa kit	>52 publications with GHR and PRL
STAT3 elisa kit	>29 publications with GHR and STAT3
GH1 elisa kit	>21 publications with GHR and GH1
SOCS3 elisa kit	>20 publications with GHR and SOCS3
IRS1 elisa kit	>15 publications with GHR and IRS1
SOCS2 elisa kit	>14 publications with GHR and SOCS2

Pathways associated with GHR elisa kit

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Growth Hormone Receptor Signaling Pathway antibodies	Growth Hormone Receptor Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with GHR elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>111 publications with GHR and Neoplasms
Nervous System Diseases Antibodies	>82 publications with GHR and Nervous System Diseases
Laron Syndrome Antibodies	>80 publications with GHR and Laron Syndrome
Disease Models, Animal Antibodies	>63 publications with GHR and Disease Models, Animal
Cardiovascular Diseases Antibodies	>50 publications with GHR and Cardiovascular Diseases
Carcinoma Antibodies	>48 publications with GHR and Carcinoma
Liver Diseases Antibodies	>48 publications with GHR and Liver Diseases
Weight Gain Antibodies	>47 publications with GHR and Weight Gain
Kidney Diseases Antibodies	>34 publications with GHR and Kidney Diseases
Necrosis Antibodies	>33 publications with GHR and Necrosis

Organs/Tissues associated with GHR elisa kit

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>17 publications with GHR and Testis
Pancreas Antibodies	>13 publications with GHR and Pancreas