GM2 Ganglioside Activator (GM2A) ELISA Kit for Human

Name: Human GM2A ELISA Kit; GM2 Ganglioside Activator; MyBioSource
Brand: MyBioSource
SKU: MBS459632
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459632

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to GM2A. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to GM2A.… More details

$575 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

GM2 Ganglioside Activator (GM2A), ELISA Kit

Full Product Name

Human GM2 Ganglioside Activator (GM2A) ELISA Kit

Product Gene Name

GM2A elisa kit

Product Synonym Names

SAP-3; Cerebroside Sulfate Activator Protein; Sphingolipid Activator Protein 3

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Tissue Homogenates or Other Biological Fluids.

Detection Range

0.156-10ng/mL

Sensitivity

0.061ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

20,838 Da

OMIM

272750

3D Structure

ModBase 3D Structure for P17900

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of GM2A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GM2A purchase

MBS459632 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GM2 Ganglioside Activator (GM2A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GM2A. The ELISA analytical biochemical technique of the MBS459632 kit is based on GM2A antibody-GM2A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GM2A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GM2A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GM2A. It may not necessarily be applicable to this product.

NCBI GI #

39995109

NCBI GeneID

2760

NCBI Accession #

NP_000396.2

UniProt Primary Accession #

P17900

UniProt Secondary Accession #

Q14426; Q14428; Q6LBL5; B2R699; D3DQH6

UniProt Related Accession #

P17900

GenBank Nucleotide #

NM_000405.4

NCBI Official Full Name

ganglioside GM2 activator isoform 1

NCBI Official Synonym Full Names

GM2 ganglioside activator

NCBI Official Symbol

GM2A

NCBI Official Synonym Symbols

SAP-3; GM2-AP

UniProt Protein Name

Ganglioside GM2 activator

UniProt Synonym Protein Names

Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3

Protein Family

Ganglioside GM2 activator

UniProt Gene Name

GM2A

UniProt Synonym Gene Names

SAP-3

NCBI Protein Information

ganglioside GM2 activator

NCBI Summary for GM2A

This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

UniProt Comments for GM2A

The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

Research Articles on GM2A

1. Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GM2A elisa kit

Reference Product	PubMed Publications
HEXB elisa kit	>9 publications with GM2A and HEXB
HEXA elisa kit	>9 publications with GM2A and HEXA
PSAP elisa kit	>1 publications with GM2A and PSAP

Pathways associated with GM2A elisa kit

Products by Pathway	Pathway Diagram
Glycosphingolipid Metabolism Pathway antibodies	Glycosphingolipid Metabolism Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Sphingolipid Metabolism Pathway antibodies	Sphingolipid Metabolism Pathway Diagram

Diseases associated with GM2A elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>10 publications with GM2A and Nervous System Diseases
Brain Diseases Antibodies	>9 publications with GM2A and Brain Diseases
Tay-Sachs Disease, AB Variant Antibodies	>8 publications with GM2A and Tay-Sachs Disease, AB Variant
Disease Models, Animal Antibodies	>4 publications with GM2A and Disease Models, Animal
Kidney Diseases Antibodies	>3 publications with GM2A and Kidney Diseases
Breast Neoplasms Antibodies	>1 publications with GM2A and Breast Neoplasms
Neoplasms Antibodies	>1 publications with GM2A and Neoplasms
Atrophy Antibodies	>1 publications with GM2A and Atrophy

Organs/Tissues associated with GM2A elisa kit

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>5 publications with GM2A and Kidney
Brain Antibodies	>4 publications with GM2A and Brain
Liver Antibodies	>3 publications with GM2A and Liver
Testis Antibodies	>2 publications with GM2A and Testis
Eye Antibodies	>1 publications with GM2A and Eye
Bone Marrow Antibodies	>1 publications with GM2A and Bone Marrow
Ovary Antibodies	>1 publications with GM2A and Ovary
Bone Antibodies	>1 publications with GM2A and Bone
Spleen Antibodies	>1 publications with GM2A and Spleen
Blood Antibodies	>1 publications with GM2A and Blood