Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) ELISA Kit for Human

Name: Human GRIA4 ELISA Kit; Glutamate Receptor, Ionotropic, AMPA 4; MyBioSource
Brand: MyBioSource
SKU: MBS459706
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459706

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to GRIA4. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to GRIA4.… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4), ELISA Kit

Full Product Name

Human Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) ELISA Kit

Product Gene Name

GRIA4 elisa kit

Product Synonym Names

GLUR4; GLUR4C; GLURD; AMPA-selective glutamate receptor 4

Species Reactivity

Human

Assay Type

Sandwich

Samples

Tissue Homogenates or Other Biological Fluids.

Detection Range

0.312-20ng/mL

Sensitivity

0.104ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

49,146 Da

OMIM

138246

3D Structure

ModBase 3D Structure for P48058

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of GRIA4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRIA4 purchase

MBS459706 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRIA4. The ELISA analytical biochemical technique of the MBS459706 kit is based on GRIA4 antibody-GRIA4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRIA4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRIA4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GRIA4. It may not necessarily be applicable to this product.

NCBI GI #

164419734

NCBI GeneID

2893

NCBI Accession #

NP_000820.3

UniProt Primary Accession #

P48058

UniProt Secondary Accession #

Q86XE8

UniProt Related Accession #

P48058

GenBank Nucleotide #

NM_000829.3

NCBI Official Full Name

glutamate receptor 4 isoform 1

NCBI Official Synonym Full Names

glutamate ionotropic receptor AMPA type subunit 4

NCBI Official Symbol

GRIA4

NCBI Official Synonym Symbols

GLUR4; GLURD; GluA4; GLUR4C; NEDSGA

UniProt Protein Name

Glutamate receptor 4

UniProt Synonym Protein Names

AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4

Protein Family

Glutamate receptor

UniProt Gene Name

GRIA4

UniProt Synonym Gene Names

GLUR4; GluR-4; GluR4; GluA4

NCBI Protein Information

glutamate receptor 4

NCBI Summary for GRIA4

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

UniProt Comments for GRIA4

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Research Articles on GRIA4

1. The authors suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRIA4 elisa kit

Reference Product	PubMed Publications
GRIA1 elisa kit	>8 publications with GRIA4 and GRIA1
CACNG2 elisa kit	>1 publications with GRIA4 and CACNG2

Pathways associated with GRIA4 elisa kit

Products by Pathway	Pathway Diagram
Activation Of AMPA Receptors Pathway antibodies	Activation Of AMPA Receptors Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Dopaminergic Synapse Pathway antibodies	Dopaminergic Synapse Pathway Diagram
Dopaminergic Synapse Pathway antibodies	Dopaminergic Synapse Pathway Diagram
Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies	Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram

Diseases associated with GRIA4 elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>14 publications with GRIA4 and Nervous System Diseases
Brain Diseases Antibodies	>11 publications with GRIA4 and Brain Diseases
Immune System Diseases Antibodies	>5 publications with GRIA4 and Immune System Diseases
Seizures Antibodies	>4 publications with GRIA4 and Seizures
Disease Models, Animal Antibodies	>3 publications with GRIA4 and Disease Models, Animal
Neoplasms Antibodies	>1 publications with GRIA4 and Neoplasms
Hyperplasia Antibodies	>1 publications with GRIA4 and Hyperplasia
Inflammation Antibodies	>1 publications with GRIA4 and Inflammation
Myopia Antibodies	>1 publications with GRIA4 and Myopia

Organs/Tissues associated with GRIA4 elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>9 publications with GRIA4 and Brain
Nerve Antibodies	>1 publications with GRIA4 and Nerve
Lymph Antibodies	>1 publications with GRIA4 and Lymph
Eye Antibodies	>1 publications with GRIA4 and Eye