Granulin (GRN) ELISA Kit for Human

Name: Human GRN ELISA Kit; Granulin; MyBioSource
Brand: MyBioSource
SKU: MBS459718
Price: 540 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS459718

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to GRN. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to GRN. Next,… More details

$540 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Granulin (GRN), ELISA Kit

Full Product Name

Human Granulin (GRN) ELISA Kit

Product Gene Name

GRN elisa kit

Product Synonym Names

GEP; GP88; PCDGF; PEPI; PGRN; Proepithelin; Acrogranin; Glycoprotein of 88 Kda; Paragranulin

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates or Other Biological Fluids.

Detection Range

1.56-100ng/mL

Sensitivity

0.62ng/mL

Preparation and Storage

For unopened kits: All the reagents should be kept at 4 degree C upon receipt.
For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Molecular Weight

44,132 Da

OMIM

138945

3D Structure

ModBase 3D Structure for P28799

RTU ELISA Kit's Advantage

The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of GRN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRN purchase

MBS459718 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Granulin (GRN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GRN. The ELISA analytical biochemical technique of the MBS459718 kit is based on GRN antibody-GRN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GRN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GRN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for GRN. It may not necessarily be applicable to this product.

NCBI GI #

4504151

NCBI GeneID

2896

NCBI Accession #

NP_002078.1

UniProt Primary Accession #

P28799

UniProt Secondary Accession #

P23781; P23782; P23783; P23784; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0; D3DX55

UniProt Related Accession #

P28799

GenBank Nucleotide #

NM_002087.3

NCBI Official Full Name

granulins

NCBI Official Synonym Full Names

granulin precursor

NCBI Official Symbol

GRN

NCBI Official Synonym Symbols

GEP; GP88; PEPI; PGRN; CLN11; PCDGF

UniProt Protein Name

Granulins

UniProt Synonym Protein Names

Proepithelin; PEPI

Protein Family

GATA-binding factor

UniProt Gene Name

GRN

UniProt Synonym Gene Names

PEPI; GP88; Glycoprotein 88

NCBI Protein Information

granulins

NCBI Summary for GRN

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

UniProt Comments for GRN

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

Research Articles on GRN

1. PGRN is involved in lysosomal homeostasis and lipid metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRN elisa kit

Reference Product	PubMed Publications
CHMP2B elisa kit	>29 publications with GRN and CHMP2B
TARDBP elisa kit	>19 publications with GRN and TARDBP
SLPI elisa kit	>8 publications with GRN and SLPI
VEGFA elisa kit	>6 publications with GRN and VEGFA
CCND1 elisa kit	>3 publications with GRN and CCND1
MMP12 elisa kit	>1 publications with GRN and MMP12
CCNT1 elisa kit	>1 publications with GRN and CCNT1

Pathways associated with GRN elisa kit

Products by Pathway	Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram

Diseases associated with GRN elisa kit

Disease Name	Pubmed Publications
Dementia Antibodies	>388 publications with GRN and Dementia
Nervous System Diseases Antibodies	>380 publications with GRN and Nervous System Diseases
Brain Diseases Antibodies	>358 publications with GRN and Brain Diseases
Frontotemporal Lobar Degeneration Antibodies	>318 publications with GRN and Frontotemporal Lobar Degeneration
Frontotemporal Dementia Antibodies	>284 publications with GRN and Frontotemporal Dementia
Inflammation Antibodies	>72 publications with GRN and Inflammation
Necrosis Antibodies	>38 publications with GRN and Necrosis
Nerve Degeneration Antibodies	>38 publications with GRN and Nerve Degeneration
Cognition Disorders Antibodies	>24 publications with GRN and Cognition Disorders
Memory Disorders Antibodies	>23 publications with GRN and Memory Disorders

Organs/Tissues associated with GRN elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>275 publications with GRN and Brain
Blood Antibodies	>163 publications with GRN and Blood
Nerve Antibodies	>66 publications with GRN and Nerve
Embryonic Tissue Antibodies	>38 publications with GRN and Embryonic Tissue
Vascular Antibodies	>35 publications with GRN and Vascular
Bone Antibodies	>29 publications with GRN and Bone
Muscle Antibodies	>26 publications with GRN and Muscle
Liver Antibodies	>26 publications with GRN and Liver
Heart Antibodies	>24 publications with GRN and Heart
Lung Antibodies	>18 publications with GRN and Lung