SOCS-5 Antibody – Rabbit Polyclonal

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of JAK-STAT cascade; negative regulation of T-helper 2 cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 1 cell differentiation; post-translational protein modification