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STAT4 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS460083

STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. Activation of STAT4 induces dimerization, nuclear… More details

$340 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
STAT4, Antibody
Full Product Name
Rabbit anti STAT4 Polyclonal Antibody
Product Gene Name
Product Synonym Names
Signal transducer and activator of transcription 4 (STAT4)
Host
Rabbit
Species Reactivity
Human, Rat, Mouse, Dog
Form/Format
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
Purity/Purification
The Rabbit IgG is purified by Epitope Affinity Purification.
Specificity
This antibody recognizes STAT4 (pY693) with a phosphorylated sites of Tyr693. It does not cross-react with non-phosphospecific peptide.
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at –20°C to –70°C. The antibodies can be stored at 2°C-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Molecular Weight
90 kDa
OMIM
L78440 mRNA
Preparation
A synthetic peptide surrounding to the C-terminus of STAT4 protein from human. This sequence is identical to mouse, rat, chicken, dog and bovine origins.
Positive Control
Mouse kidney
Nuclear Location
Nuclear
Applications Tested/Suitable for anti-STAT4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-STAT4 antibody
WB: 0.1-1 ug/ml
ELISA 0.01-0.1 ug/ml
IP: 2-5 ug/ml
IHC: 1:100 ug/ml
Optimal dilutions should be determined by researchers for the specific applications.

Western Blot (WB) of anti-STAT4 antibody

Rabbit Anti-STAT4 Antibody – Cat# MBS460083

Other Notes

Small volumes of anti-STAT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT4 purchase

MBS460083 is an antibody targeting STAT4. Also known as Rabbit anti STAT4 Polyclonal Antibody. Reactive in Human, Rat, Mouse, Dog. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
STAT4, partial
NCBI Official Synonym Full Names
signal transducer and activator of transcription 4
NCBI Official Symbol
STAT4
NCBI Official Synonym Symbols
SLEB11
UniProt Protein Name
Signal transducer and activator of transcription 4
UniProt Gene Name
STAT4
NCBI Protein Information
signal transducer and activator of transcription 4

NCBI Summary for STAT4

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
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UniProt Comments for STAT4

STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2-q32.3

Molecular Function: protein binding

Biological Process: JAK-STAT cascade

Disease: Systemic Lupus Erythematosus, Susceptibility To, 11
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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