Collagen I Antibody – Rabbit Polyclonal

Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

Oohashi, T., Sugimoto, M., Mattei, M.G. and Ninomiya, Y. Identification of a new collagen IV chain, alpha 6 (IV), by cDNA isolation and assignment of the gene to chromosome Xq22, which is the same locus for COL4A5. J. Biol. Chem. 269 (10), 7520-7526 (1994).

Small volumes of anti-Collagen I antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS460105 is an antibody targeting Collagen I. Also known as Rabbit anti Collagen I Polyclonal Antibody. Reactive in Human. Host: Rabbit.