Cyclin D1 (CCND1) Antibody – Rabbit Polyclonal

Cyclin family is highly conserved which are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. The increased expression of cyclin D1 can play a critical role in tumor development and in maintenance of the malignant phenotype, such as human neoplasms including mantle cell lymphomas (MCL). Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Tashiro E. Tsuchiya A, Imoto M. Functions of cyclin D1 as an oncognene and regulation of cyclin D1 expression. Cancer Sci, 98 (5): 629-35 (2007).

Small volumes of anti-CCND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS460117 is an antibody targeting CCND1. Also known as Rabbit anti Cyclin D1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.