BIM Antibody – Rabbit Polyclonal

Bim (bcl-2-interacting mediator of cell death, BCL-2-related Ovarian Death Gene) is a proapoptotic member of the Bcl-2 family that shares the homology domain3 (BH3) with this family. Bim exists in three isoforms: BimEL, BimL, and BimS. As the BCL-2 family members reside upstream of irreversible cellular damage and focus much of their efforts at the level of mitochondria, they play a pivotal role in deciding whether a cell will live or die. In healthy cells, BIM molecules are localized to the microtubule-associated dynein motor complex through association with the LC8 dynein light chain. Following a death signal, LC8 and BIM dissociate from the motor complex and together translocate to the mitochondria. At the mitochondria, BIM is thought to interact with BCL-2 to antagonize its antiapoptotic activity.

1. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998; 281 (5381):1322-1326.

Small volumes of anti-Bim antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS460210 is an antibody targeting Bim. Also known as Rabbit anti Bim Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.