Osteopontin (SPP1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

osteopontin: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Belongs to the osteopontin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus

Molecular Function: extracellular matrix binding; protein binding

Biological Process: androgen catabolic process; cell adhesion; cellular protein metabolic process; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; osteoblast differentiation; positive regulation of bone resorption; positive regulation of transcription, DNA-dependent; post-translational protein modification; response to vitamin D