Tenascin C (TNC) Antibody – Rabbit Polyclonal

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q33.1

Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane

Molecular Function: syndecan binding

Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; osteoblast differentiation; post-translational protein modification; response to wounding

Disease: Deafness, Autosomal Dominant 56