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RIC8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS460519

MBS460519 is an antibody targeting RIC8. Also known as Rabbit anti RIC8 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$355 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RIC8, Polyclonal Antibody
Full Product Name
Rabbit anti RIC8 Polyclonal Antibody
Product Gene Name
anti-RIC8 antibody
Product Synonym Names
Resistance to inhibitors of cholinesterase 8 homolog; RIC-8; RIC8A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purity/Purification
Purified by Epitope Affinity Purification
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Molecular Weight
59,612 Da
OMIM
AL136935 mRNA
Applications Tested/Suitable for anti-RIC8 antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-RIC8 antibody
ELISA: 0.01-0.1 ug/ml
Flow Cytometry: 5-10 ug/ml
Immunohistochemistry: 2-10 ug/ml
Immunoprecipitation: 2-5 ug/ml
Western Blot: 0.1-1 ug/ml

Other Notes

Small volumes of anti-RIC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RIC8. It may not necessarily be applicable to this product.

NCBI GI #
28925696
NCBI GeneID
60626
NCBI Accession #
EAA34708.1
UniProt Secondary Accession #
Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7
UniProt Related Accession #
Q9NPQ8
NCBI Official Full Name
RIC8
NCBI Official Synonym Full Names
RIC8 guanine nucleotide exchange factor A
NCBI Official Symbol
RIC8A
NCBI Official Synonym Symbols
RIC8
UniProt Protein Name
Synembryn-A
UniProt Synonym Protein Names
Protein Ric-8A
Protein Family
CRIB domain-containing protein
UniProt Gene Name
RIC8A
NCBI Protein Information
synembryn-A

UniProt Comments for RIC8

RIC8A: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Belongs to the synembryn family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEF; GEF, misc.

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; plasma membrane

Molecular Function: G-protein alpha-subunit binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding

Biological Process: G-protein coupled receptor protein signaling pathway
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Research Articles on RIC8

1. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RIC8 antibody

 Reference Product  PubMed Publications
 GNAI1 antibody  >1 publications with RIC8 and GNAI1

Diseases associated with anti-RIC8 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >1 publications with RIC8 and Atrophy
 Learning Disorders Antibodies  >1 publications with RIC8 and Learning Disorders

Organs/Tissues associated with anti-RIC8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with RIC8 and Brain
 Kidney Antibodies  >2 publications with RIC8 and Kidney
 Heart Antibodies  >1 publications with RIC8 and Heart
 Vascular Antibodies  >1 publications with RIC8 and Vascular
 Ovary Antibodies  >1 publications with RIC8 and Ovary
 Muscle Antibodies  >1 publications with RIC8 and Muscle
 Embryonic Tissue Antibodies  >1 publications with RIC8 and Embryonic Tissue
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