AKT1/PKBa Antibody – Rabbit

Akt [also known as PKB (Protein kinase B) is a family of serine/threonine kinases that plays an important role in signal transduction. There are three known isoforms of Akt in mammalian cells [Akt1 (alpha), Akt2 (beta) and Akt3 (gamma)]; Akt2 and Akt3 have 81% and 83% homology in amino acid sequences with Akt1, respectively. Numerous studies have revealed that the expression pattern of Akt1 and Akt2 is ubiquitous, whereas Akt3 is expressed predominantly in brain, heart, and kidney. Akt is activated by insulin and growth and survival factors.Akt has been referred to as an oncogene because it has increased activity in a number of tumors.

Kaname Nakatani, et al. Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines. THE JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 274, No. 31, Issue of July 30, pp. 21528-21532, 1999.

Small volumes of anti-AKT1/PKBa antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462004 is an antibody targeting AKT1/PKBa. Also known as Rabbit anti AKT1/PKBa antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.