Rabbit Anti-IRS-2 (pS731) Antibody – Cat# MBS462062

IRS-2 (pS731) Antibody – Rabbit

Name: IRS-2 (pS731) Antibody; Rabbit; Human/Rat/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS462062
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS462062

Insulin Receptor Substrate-2 (IRS-2), a 180kDa cytoplasmic docking protein, is one of the major endogenous substrates of the insulin receptor kinase. The insulin receptor mediates insulin action through the phosphorylation of substrate proteins. The major… More details

$355 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IRS-2 (pS731), Antibody

Full Product Name

Rabbit anti Phospho- IRS-2 (pSer 731) antibody

Product Gene Name

anti-IRS-2 (pS731) antibody

Product Synonym Names

Rabbit anti-IRS-2 (p Ser731); Anti-phospho-IRS-2 (pSer731); Insulin-receptor substrate 2 (IRS-2).

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Form/Format

This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer

Purity/Purification

The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.

Concentration

Size: 100 ug/200 ul (lot specific)

Specificity

This antibody recognizes ~180 kDa of human IRS-2 (pSer731). It also reacts with mouse and rat. The other species are not tested.

Preparation and Storage

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Molecular Weight

180 kDa

Chromosome Location

Chromosome: 13; NC_000013.10 (110406184..110438914, complement). Location: 13q34

OMIM

600797

3D Structure

ModBase 3D Structure for Q96RG4

Antigen Preparation

A synthetic peptide corresponding to the epitope ASSPA with a single phosphorylation site Ser 731 of human IRS-2.

Positive Control

3T3 cell lysate

Applications Tested/Suitable for anti-IRS-2 (pS731) antibody

ELISA, Western Blot, Immunohistochemistry

Application Notes for anti-IRS-2 (pS731) antibody

Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml

Product References and Citations for anti-IRS-2 (pS731) antibody

Li, Y. et al. (2004) J. Biol. Chem. 279, 45304-45307.

Other Notes

Small volumes of anti-IRS-2 (pS731) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRS-2 (pS731) purchase

MBS462062 is an antibody targeting IRS-2 (pS731). Also known as Rabbit anti Phospho- IRS-2 (pSer 731) antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRS-2 (pS731). It may not necessarily be applicable to this product.

NCBI GI #

38683860

NCBI GeneID

8660

NCBI Accession #

NP_003740.2

UniProt Primary Accession #

Q96RG4

UniProt Related Accession #

Q8TF73; Q96RG4; Q96RG5; Q9P084; Q9UP29; Q9Y4H2

GenBank Nucleotide #

NM_003749.2

NCBI Official Full Name

insulin receptor substrate 2

NCBI Official Synonym Full Names

insulin receptor substrate 2

NCBI Official Symbol

IRS2

NCBI Official Synonym Symbols

IRS-2

UniProt Protein Name

Insulin receptor substrate 2 insertion mutant

UniProt Gene Name

IRS2

UniProt Entry Name

Q96RG4_HUMAN

NCBI Protein Information

insulin receptor substrate 2; OTTHUMP00000018696

NCBI Summary for IRS-2 (pS731)

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq]

UniProt Comments for IRS-2 (pS731)

Sequence similarities: Contains 1 PH domain. RuleBase RU003350

Research Articles on IRS-2 (pS731)

1. In chronic hepatitis B patients the expression and tyrosine phosphorylation of IRS-2 in hepatic tissue were significantly decreased.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRS-2 (pS731) antibody

Reference Product	PubMed Publications
IGF1R antibody	>75 publications with IRS-2 (pS731) and IGF1R
GRB2 antibody	>40 publications with IRS-2 (pS731) and GRB2
JAK2 antibody	>34 publications with IRS-2 (pS731) and JAK2
SHC1 antibody	>24 publications with IRS-2 (pS731) and SHC1
JAK1 antibody	>14 publications with IRS-2 (pS731) and JAK1
SOCS3 antibody	>14 publications with IRS-2 (pS731) and SOCS3
INSR antibody	>14 publications with IRS-2 (pS731) and INSR
JAK3 antibody	>13 publications with IRS-2 (pS731) and JAK3
PTPN6 antibody	>11 publications with IRS-2 (pS731) and PTPN6
PTPN11 antibody	>10 publications with IRS-2 (pS731) and PTPN11

Pathways associated with anti-IRS-2 (pS731) antibody

Products by Pathway	Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Aldosterone-regulated Sodium Reabsorption Pathway antibodies	Aldosterone-regulated Sodium Reabsorption Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
EPO Receptor Signaling Pathway antibodies	EPO Receptor Signaling Pathway Diagram
EPO Signaling Pathway antibodies	EPO Signaling Pathway Diagram
IGF1 Pathway antibodies	IGF1 Pathway Diagram

Diseases associated with anti-IRS-2 (pS731) antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>313 publications with IRS-2 (pS731) and Insulin Resistance
Hyperinsulinism Antibodies	>212 publications with IRS-2 (pS731) and Hyperinsulinism
Neoplasms Antibodies	>121 publications with IRS-2 (pS731) and Neoplasms
Diabetes Mellitus, Type 2 Antibodies	>104 publications with IRS-2 (pS731) and Diabetes Mellitus, Type 2
Disease Models, Animal Antibodies	>62 publications with IRS-2 (pS731) and Disease Models, Animal
Hyperglycemia Antibodies	>61 publications with IRS-2 (pS731) and Hyperglycemia
Liver Diseases Antibodies	>45 publications with IRS-2 (pS731) and Liver Diseases
Fatty Liver Antibodies	>40 publications with IRS-2 (pS731) and Fatty Liver
Glucose Intolerance Antibodies	>33 publications with IRS-2 (pS731) and Glucose Intolerance
Necrosis Antibodies	>27 publications with IRS-2 (pS731) and Necrosis

Organs/Tissues associated with anti-IRS-2 (pS731) antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>187 publications with IRS-2 (pS731) and Blood
Muscle Antibodies	>166 publications with IRS-2 (pS731) and Muscle
Pancreas Antibodies	>131 publications with IRS-2 (pS731) and Pancreas
Adipose Tissue Antibodies	>77 publications with IRS-2 (pS731) and Adipose Tissue
Connective Tissue Antibodies	>64 publications with IRS-2 (pS731) and Connective Tissue
Brain Antibodies	>51 publications with IRS-2 (pS731) and Brain
Heart Antibodies	>30 publications with IRS-2 (pS731) and Heart
Kidney Antibodies	>30 publications with IRS-2 (pS731) and Kidney
Ovary Antibodies	>23 publications with IRS-2 (pS731) and Ovary
Bone Antibodies	>16 publications with IRS-2 (pS731) and Bone