Rabbit Anti-OCT-2 Antibody – Cat# MBS462094

OCT-2 Antibody – Rabbit

Name: OCT-2 Antibody; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS462094
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS462094

Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating Bcell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as… More details

$315 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OCT-2, Antibody

Full Product Name

Rabbit anti OCT-2 antibody

Product Gene Name

anti-OCT-2 antibody

Product Synonym Names

Rabbit anti-Oct-2; POU2F2

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer

Purity/Purification

The Rabbit IgG is purified by Epitope Affinity Purification.

Concentration

Size: 100 ug/200 ul (lot specific)

Specificity

This antibody recognizes ~55 kDa of OCT-2 protein from human, rat and mouse origins. It does not cross react with OCT-1, OCT-4. The other species are not tested

Preparation and Storage

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Molecular Weight

55 kDa

Chromosome Location

Chromosome: 19; NC_000019.9 (42592650..42636630, complement). Location: 19q13.2

OMIM

164176

3D Structure

ModBase 3D Structure for P09086

Antigen Preparation

A synthetic peptide corresponding to C-terminus of OCT-1 protein from human, mouse and rat origins.

Positive Control

Jurkat Cell Lysate

Applications Tested/Suitable for anti-OCT-2 antibody

ELISA, Western Blot, Immunohistochemistry

Application Notes for anti-OCT-2 antibody

Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml

Product References and Citations for anti-OCT-2 antibody

Daniel Re, et al. Oct-2 and Bob-1 Deficiency in Hodgkin and Reed Sternberg Cells. Cancer Research 61, 2080-2084 (2001).

Other Notes

Small volumes of anti-OCT-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OCT-2 purchase

MBS462094 is an antibody targeting OCT-2. Also known as Rabbit anti OCT-2 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OCT-2. It may not necessarily be applicable to this product.

NCBI GI #

4379032

NCBI GeneID

5452

UniProt Primary Accession #

P09086

UniProt Secondary Accession #

Q16648; Q7M4M8; Q9BRS4

UniProt Related Accession #

P09086; Q16624; Q9UMI6; Q9UMJ4

NCBI Official Full Name

Oct-2

NCBI Official Synonym Full Names

POU class 2 homeobox 2

NCBI Official Symbol

POU2F2

NCBI Official Synonym Symbols

OCT2; OTF2; Oct-2

UniProt Protein Name

POU domain, class 2, transcription factor 2

UniProt Synonym Protein Names

Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2

Protein Family

POU domain, class 2, transcription factor

UniProt Gene Name

POU2F2

UniProt Synonym Gene Names

OCT2; OTF2

UniProt Entry Name

PO2F2_HUMAN

NCBI Protein Information

POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; OTTHUMP00000231645; OTTHUMP00000231646; OTTHUMP00000231647; OTTHUMP00000231648; OTTHUMP00000231650; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2

NCBI Summary for OCT-2

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for OCT-2

Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Ref.2 Ref.6 Ref.8 Ref.9

Subunit structure: Interacts with NR3C1, AR and PGR. Ref.11

Subcellular location: Cytoplasm

By similarity. Nucleus.

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147. Ref.2 Ref.10

Sequence similarities: Belongs to the POU transcription factor family. Class-2 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.

Sequence caution: The sequence CAA32039.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on OCT-2

1. Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OCT-2 antibody

Reference Product	PubMed Publications
POU2AF1 antibody	>35 publications with OCT-2 and POU2AF1
TBP antibody	>4 publications with OCT-2 and TBP
HMGB2 antibody	>1 publications with OCT-2 and HMGB2

Pathways associated with anti-OCT-2 antibody

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram

Diseases associated with anti-OCT-2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>40 publications with OCT-2 and Neoplasms
Hodgkin Disease Antibodies	>11 publications with OCT-2 and Hodgkin Disease
Vascular Diseases Antibodies	>4 publications with OCT-2 and Vascular Diseases
Cell Transformation, Neoplastic Antibodies	>3 publications with OCT-2 and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>3 publications with OCT-2 and Neoplasms, Experimental
Melanoma Antibodies	>2 publications with OCT-2 and Melanoma
Liver Neoplasms Antibodies	>1 publications with OCT-2 and Liver Neoplasms
Breast Neoplasms Antibodies	>1 publications with OCT-2 and Breast Neoplasms
Genital Neoplasms, Female Antibodies	>1 publications with OCT-2 and Genital Neoplasms, Female

Organs/Tissues associated with anti-OCT-2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>114 publications with OCT-2 and Blood
Brain Antibodies	>20 publications with OCT-2 and Brain
Lymph Node Antibodies	>7 publications with OCT-2 and Lymph Node
Lymph Antibodies	>6 publications with OCT-2 and Lymph
Bone Antibodies	>6 publications with OCT-2 and Bone
Embryonic Tissue Antibodies	>3 publications with OCT-2 and Embryonic Tissue
Liver Antibodies	>3 publications with OCT-2 and Liver
Tonsil Antibodies	>2 publications with OCT-2 and Tonsil
Testis Antibodies	>2 publications with OCT-2 and Testis
Skin Antibodies	>2 publications with OCT-2 and Skin