VR1b Antibody – Rabbit Polyclonal

Arginine vasopressin (AVP) modulates the secretion of ACTH through vasopressin receptor subtype V1b (VR1b) in the pituitary. The action of vasopressin is not limited to regulating water excretion, plasma volume, plasma osmolality, and liver glycogenolysis but also plays an essential role in regulating the corticotropic acis during stress. Vasopressin is synthesized in the hypothalamus and stored in the posterior pituitary. It acts on 3 types of receptors (RV). AVP receptors are members of the G-protein coupled receptors with putative 7 transmembrane domains. VR1a are vascular receptors mediating the vasoconstrictor and glycogenolytic effects of the hormone. Anterior pituitary VR1b or V3 mediate stimulating effexts on the corticotropic axis. Renal VR2 regulate water and urea excretion. AVP mediates intracellular Ca2+ increase, glucagons secretion, and cell proliferation by activating V1b receptors.

Small volumes of anti-VR1b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462153 is an antibody targeting VR1b. Also known as VR1b rabbit antibody. Reactive in Human. Host: Rabbit.