CD156b (NT) Antibody – Rabbit Polyclonal

CD156b is a type I transmembrane glycoprotein belong to the ADAM (a disintegrin and metalloprotease domain) family. This single-pass type-1 824 aa transmembrane glycoprotein contains a signal sequence, an extracellular domain (prodomain, catalytic domain, disintegrin-cysteine-rich domain, glycosylation sites), transmembrane and cytoplasmic domain. CD156b is a multi-domain protein that includes a Zn-dependent protease domain in the extracellular portion. It releases the soluble forms of TNF and TGFa from cells. CD156b is identified by its ability to cleave the transmembrane form of TNF between Ala-76 and Val-77 to generate the soluble form. CD156b is therefore a prospective therapeutic target in human cancer. CD156b is expressed on T cells, neutrophils, endothelial cells, monocytes, dendritic cells, macrophages, polymorphonuclear leukocytes and myocytes. And non-lymphoid tissues including heart, placenta, brain, muscle.

Gooz,P., et al. ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis Biochem. Biophys. Res. Commun. 380 (1), 33-38 (2009).

Small volumes of anti-CD156b (NT) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462180 is an antibody targeting CD156b (NT). Also known as Rabbit anti CD156b/ADAM17 Polyclonal antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.