DESMIN (pT76/77) Antibody – Rabbit

Desmin is a major intermediate filament protein found exclusively in striated (skeletal or cardiac) muscle tissue. It belongs to a large family of class III intermediate filament protein, the main intermediate filamentin mature skeletal, cardiac and smooth muscle cells. Mutations in the gene encoding desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. PKC (Protein Kinase C) and cAMP-dependent protein kinase can induce disassembly of the desmin filaments by phosphorylating multiple sites at N-terminus of desmin which can affect the desmin filament structure which play a role in the regulatory process in assembly and turnover.

Xupei Huang, et al. Protein Kinase C-Mediated Desmin Phosphorylation Is Related to Myofibril Disarray in Cardiomyopathic Hamster Heart. Experimental Biology and Medicine 227:1039-1046 (2002). S Kitamura, et al. Protein kinase C phosphorylation of desmin at four serine residues within the non-alphahelical head domain. J. Biol. Chem., Vol. 264 (10), 5674-5678 (1989).

Small volumes of anti-Desmin (pT76/77) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462200 is an antibody targeting Desmin (pT76/77). Also known as Rabbit anti Desmin (pThr76/77), Phosphospecific. Reactive in Human, Mouse, Rat. Host: Rabbit.