p56-LCK (LSK) (pY505) Antibody – Rabbit

Lymphocyte specific protein tyrosine kinase (LCK) belongs to Src family protein-tyrosine kinase. It is essential for T-cell development and function. The activity p56lck is regulated by phosphorylation and dephosphorylation of two critical tyrosine residues Tyr394 and Tyr505. Tyr394 and Tyr505 are autophosphorylated after p56lck activation, whereas phosphorylation of Tyr505 is believed to be due to p50csk which negatively modulates P56lck activity. Autophosphorylation at Tyr505 of P56lck may represent an accessory mechanism for the down-regulation of the tyrosine kinase activity of P56lck.

Ngozi Monu et al. Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8+ Tumor-Infiltrating T Cells. Cancer Res 2007; 67 (23):11447-54.

Small volumes of anti-p56-LCK (LSK) (pY505) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462208 is an antibody targeting p56-LCK (LSK) (pY505). Also known as Rabbit anti Phospho- ERK1/2 (pThr202/pTyr204). Reactive in Human, Mouse, Rat, Chicken, Bovine, Canine. Host: Rabbit.