Rabbit Anti-CALUMENIN Polyclonal Antibody – Cat# MBS462223

CALUMENIN Antibody – Rabbit Polyclonal

Name: CALUMENIN Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS462223
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS462223

Calumenin (CALU) is a calcium binding protein localized in the endo/sarcoplasmic reticulum (ER) in mammalian tissues. It is involved ER and Golgi apparatus named CERC which is an acronym for its family members Cab-45, reticulocalbin, Erc-55 and Calumenin. The… More details

$355 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Calumenin, Polyclonal Antibody

Full Product Name

Rabbit anti Calumenin Polyclonal antibody

Product Gene Name

anti-Calumenin antibody

Product Synonym Names

Rabbit anti-Calumenin; CALU; Calumenin 1; 2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Form/Format

This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer

Purity/Purification

The Rabbit IgG is purified by Epitope affinity purification

Concentration

Size: 100 ug/200 ul (lot specific)

Specificity

This antibody recognizes ~48 kDa of Calumenin Protein. It cross reacts with human, mouse and rat. The other species are not tested.

Preparation and Storage

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Molecular Weight

~48 kDa

Chromosome Location

Chromosome: 7; NC_000007.13 (128379346..128411531). Location: 7q32.1

OMIM

603420

3D Structure

ModBase 3D Structure for O43852

Antigen Preparation

A synthetic peptide corresponding to the N-terminus of Calumenin protein. This sequence is identical to rat, mouse and human origins.

Positive Control

Cardiac Muscle

Cellular Location

Cytoplasmic/ER

Applications Tested/Suitable for anti-Calumenin antibody

ELISA, Western Blot, Immunohistochemistry

Application Notes for anti-Calumenin antibody

Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml

Product References and Citations for anti-Calumenin antibody

Yabe,D., et al. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. J. Biol. Chem. 272 (29), 18232-18239 (1997)

Other Notes

Small volumes of anti-Calumenin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Calumenin purchase

MBS462223 is an antibody targeting Calumenin. Also known as Rabbit anti Calumenin Polyclonal antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Calumenin. It may not necessarily be applicable to this product.

NCBI GI #

2809324

NCBI GeneID

813

UniProt Primary Accession #

O43852

UniProt Secondary Accession #

O60456; Q6FHB9; Q96RL3; Q9NR43

UniProt Related Accession #

O43852; Q6IAW5

NCBI Official Full Name

calumenin

NCBI Official Synonym Full Names

calumenin

NCBI Official Symbol

CALU

NCBI Official Synonym Symbols

FLJ90608

UniProt Protein Name

Calumenin

UniProt Synonym Protein Names

Crocalbin; IEF SSP 9302

Protein Family

Calumenin

UniProt Gene Name

CALU

UniProt Entry Name

CALU_HUMAN

NCBI Protein Information

calumenin; crocalbin; IEF SSP 9302; OTTHUMP00000212712; OTTHUMP00000212713; OTTHUMP00000212714; crocalbin-like protein; multiple EF-hand protein

NCBI Summary for Calumenin

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

UniProt Comments for Calumenin

Function: Involved in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity

Subunit structure: Interacts with GGCX

Subcellular location: Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen

By similarity. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.8 Ref.9 Ref.11

Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.

Sequence similarities: Belongs to the CREC family.Contains 6 EF-hand domains.

Research Articles on Calumenin

1. associated with arterial calcification and short-term prognosis of the outcome of patients with non-ST-elevation acute coronary syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Calumenin antibody

Products by Pathway	Pathway Diagram
Formation Of Platelet Plug Pathway antibodies	Formation Of Platelet Plug Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Platelet Activation Pathway antibodies	Platelet Activation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-Calumenin antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>248 publications with Calumenin and Lung Diseases
Lung Neoplasms Antibodies	>226 publications with Calumenin and Lung Neoplasms
Fibrosis Antibodies	>143 publications with Calumenin and Fibrosis
Inflammation Antibodies	>37 publications with Calumenin and Inflammation
Breast Neoplasms Antibodies	>37 publications with Calumenin and Breast Neoplasms
Necrosis Antibodies	>19 publications with Calumenin and Necrosis
Skin Diseases Antibodies	>15 publications with Calumenin and Skin Diseases
Neoplasm Metastasis Antibodies	>13 publications with Calumenin and Neoplasm Metastasis
Asthma Antibodies	>11 publications with Calumenin and Asthma
Liver Neoplasms Antibodies	>9 publications with Calumenin and Liver Neoplasms

Organs/Tissues associated with anti-Calumenin antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>481 publications with Calumenin and Lung
Blood Antibodies	>83 publications with Calumenin and Blood
Vascular Antibodies	>36 publications with Calumenin and Vascular
Kidney Antibodies	>31 publications with Calumenin and Kidney
Liver Antibodies	>23 publications with Calumenin and Liver
Brain Antibodies	>22 publications with Calumenin and Brain
Prostate Antibodies	>18 publications with Calumenin and Prostate
Ovary Antibodies	>17 publications with Calumenin and Ovary
Muscle Antibodies	>17 publications with Calumenin and Muscle
Intestine Antibodies	>14 publications with Calumenin and Intestine