FOXA-2 Antibody – Rabbit Polyclonal

The forkhead box gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 plays an important role in breast cancer. The FOXA subfamily is composed of the transcription factors FOXA1, A2, A3. They were discovered as the regulators of hepatic genes. Regularly, the plasma insulin inhibits the forkhead transcription factor Foxa2. The cytoplasmic localization and inactivation of Foxa2 are observed in the chronic hyperinsulinaemia of insulin-resistant syndromes, thereby promoting lipid accumulation and insulin resistance in the liver. harmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes.

Wolfrum C, et al. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature, 2004 Dec 23;432 (7020):1027-32.

Small volumes of anti-FOXA-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462237 is an antibody targeting FOXA-2. Also known as Rabbit anti FOXA2/HNF3B Polyclonal antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.