COVID 19 Nucleocapsid (Np) Coronavirus (COVID-19) Antibody – Rabbit Polyclonal

The SARS-CoV-2 nucleocapsid (N) is a 45 kDa protein, one of the major structural proteins of the virus. It binds directly to viral RNA and provides stability. N-protein is involved in the transcription and viral RNA replication, packaging of the encapsidated genome into helical ribonucleocapsid, and interference with cell cycle processes of host cells. This most abundant protein of coronavirus is composed of two structural domains and a linker region. N-protein contains two independent RNA binding domains, the N-terminal RNA binding domain and a C-terminal domain, which can interact with the viral RNA to form the ribonucleoprotein. The linker region binds to the M protein. The N-protein is a highly immunogenic phosphoprotein and is extremely conserved. This protein is a repressor of RNA interference and an antagonist of interferon.

Coronaviruses are a family of viruses that can cause diseases in animals and humans that vary between the common cold and more severe diseases that include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). SARS-CoV-2 belongs to the broad family of coronaviruses. It is an enveloped positive-sense RNA virus. SARS-CoV-2 contains four structural proteins: E (envelope), M (membrane), S (spike), and N (nucleocapsid) proteins.

Coronavirus S protein is a large, multifunctional class I viral transmembrane protein. It is required for the entry of the virion particles into the cell through a contact with host cellular receptors. The S-protein of coronavirus consists of S1 and S2 functional units. S1 is responsible for host receptor binding, S2 is in charge of fusion. The nucleocapsid (N) is a 45 kDa protein, one of the major structural proteins of the virus. It binds directly to viral RNA and provides stability. It is involved in viral RNA transcription and replication, packaging of the genome into helical ribonucleocapsid, and interference with cell cycle processes of host cells.

Since its discovery in late December 2019, the novel coronavirus-related pneumonia COVID-19 continues to disseminate. Studies indicate that lung involvement is present in many cases, SARS-CoV-2 invades the lung parenchyma, resulting in severe interstitial inflammation of the lungs. It was shown before that histological examination indicated bilateral diffuse alveolar damage with cellular fibromyxoid exudates. Chest computer tomography displays the presence of lesions in lung lobes.

Our polyclonal antibodies can detect the presence of nucleocapsid (N) and spike (S) proteins in tissues of SARS-CoV-2 infected individuals.

F. K. Yoshimoto Protein J. 2020; 39(3): 198–216. Liu, W. et al. J. Clin. Microbiol. 2020 doi: 10.1128/JCM.00461-20. J. Wu, et al. Front Microbiol. 2020; 11: 1576. Published online 2020 Jul 3

Small volumes of anti-COVID-19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS462256 is an antibody targeting COVID-19. Also known as SARS-COV-2 N (nucleocapsid) protein. Host: Rabbit.