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CEACAM7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS468002

Background: CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family (1). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CEACAM7, Monoclonal Antibody
Full Product Name
anti-human CEACAM7 monoclonal antibody
Product Gene Name
anti-CEACAM7 antibody
Product Synonym Names
CGM2
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BAC2
Host
Mouse
Species Reactivity
Human
Form/Format
Purified
Purity/Purification
Protein G
Specificity
anti-human CEACAM7 (CGM2)
Preparation and Storage
Short term: 2 degree C - 8 degree C; long term: -20 degree C (avoid repeated freezing and thawing)
Molecular Weight
19,031 Da
3D Structure
ModBase 3D Structure for Q14002
Buffer
phosphate buffered saline, pH 7.2
Immunogen
CEACAM7/Fc fusion protein
Selection
based on recognition of the complete native protein expressed on transfected mammalian cells
Applications Tested/Suitable for anti-CEACAM7 antibody
Flow Cytometry, CELISA, ELISA (EIA), Western Blot (WB) and Immunohistology on cryosections
Application Notes for anti-CEACAM7 antibody
Flow Cytometry: 1.2 ug/10^6 cells
CELISA: 1:200 - 1:400

Testing Data of anti-CEACAM7 antibody

Fig.1: FACS analysis of BOSC23 cells using BAC2 Cat.# GM-0508. BOSC23 cells were transiently transfected with an expression vector encoding either CEACAM7 (red curve) or an irrelevant protein (control transfectant). Binding of BAC2 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with CEACAM7 transfected cells.
Mouse Anti-CEACAM7 Monoclonal Antibody – Cat# MBS468002

Testing Data #2 of anti-CEACAM7 antibody

Fig. 2: Members of the CEACAM family were expressed on BOSC cells after transient transfection with expression vectors containing either the cDNA of CEACAM1, 5, 6, 7, 8 or a recombinant trans-membraneanchored PSG1 fusion protein. Recognition of CEACAM3, CEACAM4 and PSG1 was tested on stably transfected HeLa (CEACAM3, PSG) and CHO cells (CEACAM4), respectively. Expression of the constructs was confirmed with monoclonal antibodies known to recognize the corresponding proteins (CEACAM1, 3, 4, 5 and 6: D14HD11; CEACAM7: CAC2; CEACAM8: TET2; PSG: BAP1; green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G purified BAC2 was tested on all CEACAM transfectants. A positive signal was only obtained with CEACAM7 expressing cells (red curves).
Mouse Anti-CEACAM7 Monoclonal Antibody, Testing Data #2 – Cat# MBS468002

Product References and Citations for anti-CEACAM7 antibody

Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
Schoelzel S et al. (2000): Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol, 156/2: 595-605
Hammarström S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81.
Grunert F, Stocks SC, Nagel G., Zimmermann W, Thompson JA, Jantscheff P and Kromer B. (1996). CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules. In Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto et al., eds.), Garland Publishing Inc., New York and London, pp. 1012-1025.

Other Notes

Small volumes of anti-CEACAM7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CEACAM7 purchase

MBS468002 is an antibody targeting CEACAM7. Also known as anti-human CEACAM7 monoclonal antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CEACAM7. It may not necessarily be applicable to this product.

NCBI GI #
612407773
NCBI GeneID
1087
NCBI Accession #
NP_001278414.1
UniProt Primary Accession #
Q14002
UniProt Secondary Accession #
O15148; O15149; Q0VAC1; Q13983; Q9UPJ2; A8K848
UniProt Related Accession #
Q14002
GenBank Nucleotide #
NM_001291485.1
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 7
NCBI Official Symbol
CEACAM7
NCBI Official Synonym Symbols
CEA; CGM2
UniProt Synonym Protein Names
Carcinoembryonic antigen CGM2
Protein Family
Carcinoembryonic antigen-related cell adhesion molecule
UniProt Gene Name
CEACAM7
UniProt Synonym Gene Names
CGM2
UniProt Entry Name
CEAM7_HUMAN
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 7; carcinoembryonic antigen CGM2; carcinoembryonic antigen gene family member 2

NCBI Summary for CEACAM7

This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
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UniProt Comments for CEACAM7

CEACAM7: Belongs to the immunoglobulin superfamily. CEA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane; integral to membrane
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Research Articles on CEACAM7

1. High CEACAM7 is associated with gastric carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CEACAM7 antibody

 Reference Product  PubMed Publications
 CEACAM1 antibody  >13 publications with CEACAM7 and CEACAM1
 CEACAM6 antibody  >12 publications with CEACAM7 and CEACAM6
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