Mouse Anti-CEACAM6 Monoclonal Antibody – Cat# MBS468045

Fig2: Members of the CEA family were expressed on BOSC cells after transient transfection with expression vectors containing either the cDNA of CEACAM1, 5, 6, 7 or 8. Recognition of CEACAM3 was tested on stably transfected HeLa cells (CEACAM4). Expression of the constructs was confirmed with monoclonal antibodies known to recognize the corresponding proteins (CEACAM1, 3, 5 and 6: D14HD11; CEACAM7: CAC2; CEACAM8: 80H3 (green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G-purified 9A6 was tested on all CEACAM transfectants. A positive signal was only obtained with CEACAM6-expressing cells (red curves).

CEACAM6 Antibody – Mouse Monoclonal

Name: CEACAM6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS468045
Price: 615 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS468045

Background: CEA-related cell adhesion molecule 6 (CEACAM6, NCA) belongs to the carcinoembryonic antigen (CEA) gene family (1,2). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 90,000 which is strongly expressed on… More details

$615 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CEACAM6, Monoclonal Antibody

Full Product Name

anti-human CEACAM6 monoclonal antibody

Product Gene Name

anti-CEACAM6 antibody

Product Synonym Names

CD66c; NCA

Clonality

Monoclonal

Isotype

IgG1

Clone Number

9A6

Host

Mouse

Species Reactivity

Human

Form/Format

Purified

Purity/Purification

Protein G

Specificity

anti-human CEACAM6 (NCA; CD66c)

Preparation and Storage

Short term: 2 degree C - 8 degree C; long term: -20 degree C (avoid repeated freezing and thawing)

Molecular Weight

37,195 Da

OMIM

163980

3D Structure

ModBase 3D Structure for P40199

Buffer

phosphate buffered saline, pH 7.2

Immunogen

tumor cell lines expressing CEACAM6

Selection

based on recognition of the complete native protein expressed on transfected mammalian cells

Applications Tested/Suitable for anti-CEACAM6 antibody

Flow Cytometry, CELISA, ELISA (EIA), Western Blot (WB) and Immunohistology on cryosections

Application Notes for anti-CEACAM6 antibody

Immunohistology: 1-2 ug/10^6 cells (on cryosections)
ELISA: 1:200 - 1:400
Western Blot: 4ug/ml
Flow Cytometry: 1.2 ug/10^6 cells
CELISA: 1:200 - 1:400

Product References and Citations for anti-CEACAM6 antibody

Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
Hammarström S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 9, 67-81.
Scholzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B and Thompson J (2000). Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol 156, 595-605.
Grunert F, Stocks SC, Nagel G., Zimmermann W, Thompson JA, Jantscheff P and Kromer B. (1996). CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66 Subsection antibodies to HeLa transfectants expressing individual CD66 molecules. In Leukocyte Typing VI: White cell Differentiation Antigens (T. Kishimoto et al., eds.), Garland Publishing Inc., New York and London, pp. 1012-1025.

Other Notes

Small volumes of anti-CEACAM6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CEACAM6 purchase

MBS468045 is an antibody targeting CEACAM6. Also known as anti-human CEACAM6 monoclonal antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CEACAM6. It may not necessarily be applicable to this product.

NCBI GI #

612407822

NCBI GeneID

4680

NCBI Accession #

NP_002474.4

UniProt Primary Accession #

P40199

UniProt Secondary Accession #

Q13774; Q14920; Q53XP7

UniProt Related Accession #

P40199

GenBank Nucleotide #

NM_002483.6

NCBI Official Full Name

carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

NCBI Official Synonym Full Names

carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)

NCBI Official Symbol

CEACAM6

NCBI Official Synonym Symbols

NCA; CEAL; CD66c

UniProt Synonym Protein Names

Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c

Protein Family

Carcinoembryonic antigen-related cell adhesion molecule

UniProt Gene Name

CEACAM6

UniProt Synonym Gene Names

NCA

UniProt Entry Name

CEAM6_HUMAN

NCBI Protein Information

carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; Cluster of Differentiation 66c

NCBI Summary for CEACAM6

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

UniProt Comments for CEACAM6

CEACAM6: Belongs to the immunoglobulin superfamily. CEA family

Protein type: Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell-cell signaling; blood coagulation; signal transduction; leukocyte migration

Research Articles on CEACAM6

1. CEACAM6 expression was expressed in different molecular subtypes of breast cancer. Among different subtypes, the highest expression was found with HER2 positive cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CEACAM6 antibody

Reference Product	PubMed Publications
CEACAM5 antibody	>112 publications with CEACAM6 and CEACAM5
CEACAM1 antibody	>53 publications with CEACAM6 and CEACAM1
CEACAM8 antibody	>19 publications with CEACAM6 and CEACAM8
CEACAM7 antibody	>12 publications with CEACAM6 and CEACAM7
SRC antibody	>12 publications with CEACAM6 and SRC
HLA-A antibody	>2 publications with CEACAM6 and HLA-A
SOX9 antibody	>1 publications with CEACAM6 and SOX9

Diseases associated with anti-CEACAM6 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>40 publications with CEACAM6 and Carcinoma
Adenocarcinoma Antibodies	>32 publications with CEACAM6 and Adenocarcinoma
Inflammation Antibodies	>18 publications with CEACAM6 and Inflammation
Breast Neoplasms Antibodies	>13 publications with CEACAM6 and Breast Neoplasms
Lymphoma Antibodies	>12 publications with CEACAM6 and Lymphoma
Lung Neoplasms Antibodies	>9 publications with CEACAM6 and Lung Neoplasms
Necrosis Antibodies	>7 publications with CEACAM6 and Necrosis
Liver Neoplasms Antibodies	>5 publications with CEACAM6 and Liver Neoplasms
Carcinoma, Squamous Cell Antibodies	>4 publications with CEACAM6 and Carcinoma, Squamous Cell
Neoplasms, Experimental Antibodies	>4 publications with CEACAM6 and Neoplasms, Experimental