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Interleukin-17 Receptor B (IL17RB) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS468049

Purified monoclonal rat antibodyThe IL17RB protein is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C (1, 2). This receptor has been shown to mediate the activation of NF-kappaB and the… More details

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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-17 Receptor B (IL17RB), Monoclonal Antibody
Full Product Name
Rat anti-human Interleukin-17 Receptor B (IL17RB) monoclonal antibody
Product Gene Name
anti-IL17RB antibody
Clonality
Monoclonal
Isotype
IgG2b/kappa
Clone Number
BFI-7C7
Host
Rat
Purity/Purification
Protein G
Specificity
anti-human IL17RB
Preparation and Storage
Short term: 2-8°C
Long term: -20°C.
Avoid repeated freezing and thawing.
OMIM
605458
Buffer
Phosphate buffered saline, pH 7.2
Immunogen
Genetic immunisation with cDNA encoding the extracellular domain (ecd) of human IL17RB
Selection
Based on recognition of the ecd region of IL17RB on viable, transfected mammalian cells
Applications Tested/Suitable for anti-IL17RB antibody
Flow Cytometry (FC), ELISA (EIA), C-ELISA (EIA)
Application Notes for anti-IL17RB antibody
Flow Cytometry: 1.2 ug/106 cells
ELISA: 1:200 - 1:400
C-ELISA: 1:200 - 1:400

For each application a titration should be performed to determine the optimal concentration.

Flow Cytometry (FC) of anti-IL17RB antibody

Fig.1: MBS468049. BOSC23 cells were transiently transfected with an expression vector encoding either the ecd of human IL17RB (filled red curve), or an irrelevant protein (control transfectant, black curve). Binding of BFI-7C7 was detected with a PEconjugated secondary antibody. A positive signal was obtained only with human IL17RB.
Rat Anti-IL17RB Monoclonal Antibody – Cat# MBS468049

Testing Data of anti-IL17RB antibody

Fig.2: CGE analysis of purified BFI-7C7 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 mug of purified BFI-7C7 antibody. Proteins were separated by CGE (capillary gel electrophoresis, Agilent 2100 Bioanalyzer). Internal control bands (240 kDa / 7 kDa / 4,5 kDa).
Rat Anti-IL17RB Monoclonal Antibody, Testing Data – Cat# MBS468049

Product References and Citations for anti-IL17RB antibody

1. Rickel EA et al. (2008). Identification of functional roles for both IL-17RB and IL-17Ra in mediating IL-25-induced activities. J. Immunol. 181(6):4299-4310.
2. Reynolds JM et al. (2015). Interleukin-17B antagonizes Interleukin-25-mediated mucosal inflammation. Immunity 42(4):692-703.
3. Maezawa Y et al. (2006). Involvement of TNF receptor-associated factor 6 in IL-25 receptor signalling. J. Immunol. 176(2):1013-1018.
4. Hata K et al. (2002). IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 282(6):G1035-1044.

Other Notes

Small volumes of anti-IL17RB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17RB purchase

MBS468049 is an antibody targeting IL17RB. Also known as Rat anti-human Interleukin-17 Receptor B (IL17RB) monoclonal antibody. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17RB. It may not necessarily be applicable to this product.

NCBI GI #
27477074
NCBI GeneID
55540
NCBI Accession #
NP_061195.2
UniProt Secondary Accession #
Q9BPZ0; Q9NRL4; Q9NRM5
UniProt Related Accession #
Q9NRM6
GenBank Nucleotide #
NM_018725.3
NCBI Official Full Name
interleukin-17 receptor B
NCBI Official Synonym Full Names
interleukin 17 receptor B
NCBI Official Symbol
IL17RB
NCBI Official Synonym Symbols
CRL4; EVI27; IL17BR; IL17RH1
UniProt Protein Name
Interleukin-17 receptor B
UniProt Synonym Protein Names
Cytokine receptor-like 4; IL-17 receptor homolog 1; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor
Protein Family
Interleukin-17 receptor
UniProt Gene Name
IL17RB
UniProt Synonym Gene Names
CRL4; EVI27; IL17BR; IL-17 receptor B; IL-17RB; IL-17Rh1; IL17Rh1; IL-17B receptor
UniProt Entry Name
I17RB_HUMAN
NCBI Protein Information
interleukin-17 receptor B

NCBI Summary for IL17RB

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL17RB

IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cell surface; cytoplasm; extracellular region; integral to plasma membrane; membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-17 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; defense response; positive regulation of inflammatory response; regulation of cell growth
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Research Articles on IL17RB

1. IL-17RB has an essential role in pancreatic cancer growth, invasion, and metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL17RB antibody

 Reference Product  PubMed Publications
 IL17C antibody  >22 publications with IL17RB and IL17C
 HOXB13 antibody  >20 publications with IL17RB and HOXB13
 IL25 antibody  >6 publications with IL17RB and IL25
 IL17B antibody  >2 publications with IL17RB and IL17B
 IL17D antibody  >1 publications with IL17RB and IL17D

Pathways associated with anti-IL17RB antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL17 Signaling Pathway antibodies  IL17 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-17 Signaling Pathway antibodies  Interleukin-17 Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram

Diseases associated with anti-IL17RB antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >20 publications with IL17RB and Breast Neoplasms
 Inflammation Antibodies  >18 publications with IL17RB and Inflammation
 Neoplasms, Experimental Antibodies  >6 publications with IL17RB and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >5 publications with IL17RB and Cardiovascular Diseases
 Atherosclerosis Antibodies  >3 publications with IL17RB and Atherosclerosis
 Necrosis Antibodies  >3 publications with IL17RB and Necrosis
 Neoplasm Metastasis Antibodies  >2 publications with IL17RB and Neoplasm Metastasis
 Renal Insufficiency Antibodies  >1 publications with IL17RB and Renal Insufficiency
 Fibrosis Antibodies  >1 publications with IL17RB and Fibrosis
 Hyperplasia Antibodies  >1 publications with IL17RB and Hyperplasia

Organs/Tissues associated with anti-IL17RB antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with IL17RB and Lung
 Lymph Node Antibodies  >5 publications with IL17RB and Lymph Node
 Placenta Antibodies  >2 publications with IL17RB and Placenta
 Kidney Antibodies  >2 publications with IL17RB and Kidney
 Testis Antibodies  >1 publications with IL17RB and Testis
 Heart Antibodies  >1 publications with IL17RB and Heart
 Nerve Antibodies  >1 publications with IL17RB and Nerve
 Muscle Antibodies  >1 publications with IL17RB and Muscle
 Liver Antibodies  >1 publications with IL17RB and Liver
 Uterus Antibodies  >1 publications with IL17RB and Uterus
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