Akt (N-Terminal Region) Antibody – Mouse Monoclonal

Akt (PKB, Rac kinase) is a 60kDa ser/thr kinase critical for controlling diverse cellular functions, including glucose metabolism, gene transcription, cell proliferation, and apoptosis. Akt phosphorylates a number of substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. Akt is activated in response to insulin and growth factors in a PI3-kinase dependent manner. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate, which induces membrane translocation of Akt coincident with its phosphorylation at Thr-308 and Ser-473. Upon activation, Akt associates with members of the PKC family of kinases, such as PKC-delta and PKC-zeta. Ceramide-activated PKC-zeta leads to phosphorylation of Thr-34 within the pleckstrin homology domain of Akt. This phosphorylation inhibits PIP3 binding to Akt preventing activation of the kinase and may lead to cermide-induced cell death.

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• Smith, M.A. et al. (2007) Am. J. Phys. Cell. Phys. 293:1947. (WB: mouse C2C12)
• Moylan, J.S. et al. (2008) Am. J. Phys. Cell. Phys. 295:986. (WB: mouse C2C12)

Small volumes of anti-Akt (N-terminal Region) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS470001 is an antibody targeting Akt (N-terminal Region). Reactive in Human, Rat, Mouse. Host: Mouse.