B-Dystroglycan (Tyr-892) Antibody – Mouse Monoclonal

Dystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post-translationally cleaved into a 156 kDa extracellular peripheral membrane protein called a-dystroglycan and a 43 kDa transmembrane protein, b-dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain-containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c-Src interactions with beta-dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta-dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr-892 leads to localization of beta-dystroglycan to endosomal compartments along with c-Src. Thus, phosphorylation at Tyr-892 may have important roles in altering the localization of beta-dystroglycan during NMJ formation.

• James, M. et al. (2000) J Cell Sci. 113(Pt 10):1717-1726.
• Sotgia, F. et al. (2003) Biochem. 42(23):7110-7123.

Small volumes of anti-b-Dystroglycan (Tyr-892) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS470003 is an antibody targeting b-Dystroglycan (Tyr-892). Also known as beta-Dystroglycan (Tyr-892), phospho-specific. Reactive in Human, Rat, Mouse. Host: Mouse.