Integrin B4 (Cytoplasmic Region) Antibody – Mouse Monoclonal

Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin alpha-6-beta-4receptors are found in basement membrane along with laminin-5. These receptors are expressed in epithelial, schwann, endothelial and some immune cells. The cytoplasmic domain of the integrin-beta4 subunit recruits the adaptor protein Shc and is required for assembly of hemidesmosomes. Tyrosine phosphorylation of multiple sites within the cytoplasmic domain regulates these cellular events. In particular, tyrosine 1526 interacts with the phosphotyrosine binding domain of Shc and is required for Shc activation. In addition, tyrosine 1494 is required for integrin-mediated IRS-2 phosphorylation and activation of PI3-kinase. More importantly this site is critical for integrin alpha6-beta-4 increases in carcinoma invasion.

• Dans, M. et al. (2001). J Biol Chem. 276(2):1494-1502.
• Shaw, L.M. (2001). Mol Cell Biol. 21(15):5082-5093.

Small volumes of anti-Integrin b4 (Cytoplasmic Region) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS470017 is an antibody targeting Integrin b4 (Cytoplasmic Region). Also known as Integrin beta4 (Cytoplasmic Region). Reactive in Human. Host: Mouse.