• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Paxillin (PXN) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS470022

Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases,… More details

$535 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Paxillin (Pxn), Monoclonal Antibody
Full Product Name
Anti-Paxillin
Product Gene Name
anti-Pxn antibody
Product Synonym Names
Paxillin; Paxillin
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Species Reactivity
Human, Rat, Mouse, Chicken
Form/Format
Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
Purity/Purification
Protein A Purified
Specificity
This antibody detects a 68kDa* protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells. Similar results were seen in various cells and tissues from rat, mouse, and chicken origin.
Preparation and Storage
Store at -20 degree C. Do not aliquot. Stable for 1 year.
Molecular Weight
63888 Da
Chromosome Location
Chromosome: 12; NC_005111.2 (42322193..42370507, complement). Location: 12q16
3D Structure
ModBase 3D Structure for Q66H76
Immunogen
Clone (M107) was generated from full-length recombinant human paxillin.
Applications Tested/Suitable for anti-Pxn antibody
ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation
Application Notes for anti-Pxn antibody
WB: 1:1000; ELISA: 1:2000; IP: 1:100; ICC: 1:100

Western Blot of anti-Pxn antibody

Mouse Anti-PXN Monoclonal Antibody – Cat# MBS470022

Immunocytochemistry of anti-Pxn antibody

Mouse Anti-PXN Monoclonal Antibody, Immunocytochemistry – Cat# MBS470022

Product References and Citations for anti-Pxn antibody

• Huang, C. et al. (2003) Nature 424:219-223.
• Huang, C. et al. (2004) Cell Cycle 3(1):4-6.
• Woodrow, M.A. (2003) Exp. Cell. Res. 287(2):325-338.

Other Notes

Small volumes of anti-Pxn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pxn purchase

MBS470022 is an antibody targeting Pxn. Also known as Anti-Paxillin. Reactive in Human, Rat, Mouse, Chicken. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Pxn. It may not necessarily be applicable to this product.

NCBI GI #
58865866
NCBI GeneID
360820
NCBI Accession #
NP_001012147.1
UniProt Primary Accession #
Q66H76
UniProt Related Accession #
Q1EG89; Q66H76
GenBank Nucleotide #
NM_001012147.1
NCBI Official Full Name
paxillin
NCBI Official Synonym Full Names
paxillin
NCBI Official Symbol
Pxn
NCBI Official Synonym Symbols
Pxn
UniProt Protein Name
Paxillin
Protein Family
Paxillin
UniProt Gene Name
Pxn
UniProt Entry Name
PAXI_RAT
NCBI Protein Information
paxillin; myocardial ischemic preconditioning associated protein 7

UniProt Comments for Pxn

Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)

Subunit structure: Binds to vinculin, to the SH3 domain of c-SRC and to focal adhesion kinase. Interacts with GIT1 and NUDT16L1/SDOS. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2 and PDCD10

By similarity. Interacts with PARVA and TGFB1I1. Ref.2 Ref.3

Subcellular location: Cytoplasm › cytoskeleton

By similarity. Cell junction › focal adhesion

Post-translational modification: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens

By similarity. Ref.4

Sequence similarities: Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.
Show more

Research Articles on Pxn

1. Talin and paxillin showed a major distributional change between different hormone regimes, estrogen and progesterone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Pxn antibody

 Reference Product  PubMed Publications
 Ilk antibody  >8 publications with Pxn and Ilk

Pathways associated with anti-Pxn antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Gab1 Signalosome Pathway antibodies  Gab1 Signalosome Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram

Diseases associated with anti-Pxn antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >171 publications with Pxn and Neoplasms
 Neoplasm Metastasis Antibodies  >32 publications with Pxn and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >29 publications with Pxn and Breast Neoplasms
 Inflammation Antibodies  >23 publications with Pxn and Inflammation
 Cell Transformation, Neoplastic Antibodies  >21 publications with Pxn and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >19 publications with Pxn and Adenocarcinoma
 Leukemia Antibodies  >16 publications with Pxn and Leukemia
 Lung Diseases Antibodies  >16 publications with Pxn and Lung Diseases
 Neoplasms, Experimental Antibodies  >16 publications with Pxn and Neoplasms, Experimental
 Necrosis Antibodies  >14 publications with Pxn and Necrosis

Organs/Tissues associated with anti-Pxn antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >65 publications with Pxn and Muscle
 Lung Antibodies  >36 publications with Pxn and Lung
 Kidney Antibodies  >36 publications with Pxn and Kidney
 Embryonic Tissue Antibodies  >29 publications with Pxn and Embryonic Tissue
 Brain Antibodies  >26 publications with Pxn and Brain
 Heart Antibodies  >19 publications with Pxn and Heart
 Colon Antibodies  >18 publications with Pxn and Colon
 Eye Antibodies  >17 publications with Pxn and Eye
 Prostate Antibodies  >12 publications with Pxn and Prostate
 Placenta Antibodies  >7 publications with Pxn and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000