PKC Antibody – Mouse Monoclonal

The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half interacts with PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester, while the C-terminal half contains the catalytic domain. The conventional PKC subfamily (alpha, beta-I, beta-II, and gamma) is regulated by both Ca2+ and diacylglycerol. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. The phosphorylation of multiple sites in conventional PKCs regulates their activity. In mast cells, Fc-epsilon-RI stimulation leads to phosphorylation of tyrosine 658 and 662 of PKC-beta-I and PKC-alpha, respectively. This phosphorylation requires autophosphorylation of serine 657 and 661 in these respective kinases.

• Kawakami et al. (2003) Proc. Natl. Acad. Sci. USA 100:9470-9475.
• Nishizuka, Y. (1988) Nature 334:661.

Small volumes of anti-PKC (alpha, beta, gamma) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS470024 is an antibody targeting PKC (alpha, beta, gamma). Reactive in Human, Rat, Mouse. Host: Mouse.