B-Catenin (N-Terminal) (ctnnb1) Antibody – Rabbit Polyclonal

beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of ECadherin eliminate catenin binding and result in a loss of cell adhesion. Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions. Both Fer and Fyn kinases phosphorylate tyrosine 142 in vitro. Overexpression of these kinases in epithelial cells disrupts interactions between alpha and beta-Catenins. The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin. Src family kinases can also phosphorylate tyrosine 654 in the C terminal armadillo repeat of beta-Catenin. This phosphorylation regulates beta-Catenin binding to E cadherin. Thus, sitespecific tyrosine phosphorylation of beta-Catenin may regulate specific protein-protein interactions leading to changes in cell adhesion.

• Brembeck, F.H. et al. (2004) Genes Dev. 18(18):2225-2230.
• Ozawa, M. et al. (1990) Proc. Natl. Acad. Sci. USA 87:4246.
• Piedra, J. et al. (2003) Mol. Cell. Biol. 23(7):2287-2297.

Small volumes of anti-ctnnb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472003 is an antibody targeting ctnnb1. Also known as Anti-beta-Catenin (N-terminal). Reactive in Human, Rat, Mouse. Host: Rabbit.