Beta-Tubulin (Ser-172) Antibody – Rabbit Polyclonal

Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization. MTs are dynamic polymers of a/b-tubulin heterodimers. At least two populations of MTs, called dynamic and stable according to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) are among the best-known factors that regulate MT dynamics and stability. In addition, a variety of different post-translational modifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occur on serine, threonine, and tyrosine residues in b-tubulin isoforms. Multiple kinases can phosphorylate Ser-444 at the C-terminus of bIII-tubulin in vitro. Unphosphorylated Ser-444 in bIII-tubulin is an early marker for cells of neuronal lineage, while phosphorylation of Ser-444 is upregulated after neuronal maturation and may preferentially occur in assembled MTs. By contrast, Cdk1 phosphorylation of Ser-172 in b-tubulin occurs in mitotic cells and may impair tubulin incorporation into microtubules.

• Fourest-Lieuvin, A. et al. (2006) Mol. Biol. Cell. 17(3):1041.
• Westermann, S. & Weber, K. (2003) Nat. Rev. Mol. Cell. Biol. 4:938.
• Fanarraga, M.L. et al. (1999) Eur. J. Neurosci. 11:517.
• Diaz-Nido, J. et al. (1990) J Biol. Chem. 265(23):13949.

Small volumes of anti-beta-Tubulin (Ser-172) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472009 is an antibody targeting beta-Tubulin (Ser-172). Also known as beta-Tubulin (Ser-172), phospho-specific. Reactive in Human, Rat, Mouse, Chicken. Host: Rabbit.