G-Catenin (Tyr-550) Antibody – Rabbit Polyclonal

Plakoglobin (gamma-catenin) is a catenin family member that was identified as a component of desmosomes. It associates with various cell adhesion related proteins, such as desmoglein and cadherins. gamma-Catenin has high homology to beta-catenin and, like beta-catenin, it can associate with the cadherins, E-cadherin and N-cadherin. It has been proposed that one molecule of alpha catenin and at least one molecule of beta-catenin and gamma-catenin simultaneously bind to a single cadherin molecule. A 19-amino acid sequence of desmoglein was found to be critical for binding of gamma-catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for gamma-catenin localization at both adherens junctions and desmosomes. Phosphorylation of tyrosine residues in gamma-catenin can modify its interactions with other proteins. Phosphorylation of tyrosine 644 decreases gamma- catenin association with alpha-catenin, but increases binding to desmoplakin. Fer kinase can phosphorylate tyrosine 550, which increases gamma-catenin binding to alpha-catenin. Thus, tyrosinephosphorylation may be important for regulation of gamma-catenin protein-protein interactions within desmosomal complexes.

• McCrea, P.D., et al. (1991) Science 254:1359.
• Miravet, S. et al. (2003) Mol. Cell. Biol. 23(20) :7391.

Small volumes of anti-g-Catenin (Tyr-550) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472026 is an antibody targeting g-Catenin (Tyr-550). Also known as Anti-gamma-Catenin (Tyr-550), phospho-specific. Reactive in Human, Rat, Mouse. Host: Rabbit.