I-Kappa-Ba (Tyr-305) Antibody – Rabbit Polyclonal

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkB proteins. Activation of IkBa ?occurs through both serine and tyrosine phosphorylation events. Activation through phosphorylation at Ser-32 and Ser-36 is followed by proteasome-mediated degradation, resulting in the release and nuclear translocation of active NF-kB. This pathway of IkBa regulation occurs in response to various NF-kB-activating agents, such as TNF-alpha, interleukins, LPS, and irradiation. An alternative pathway for IkBa regulation occurs through tyrosine phosphorylation of Tyr-42 and Tyr-305. Tyr-42 is phosphorylated in response to oxidative stress and growth factors. This phosphorylation can lead to degradation of IkB-alpha and NF-kB-activation. In contrast, Tyr-305 phosphorylation by c-Abl has been implicated in IkB-alpha nuclear translocation and inhibition of NF-kB-activation. Thus, tyrosine phosphorylation of IkB-alpha may be an important regulatory mechanism in NF-kB signaling.

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• Waris et al. (2003) J Biol Chem 278(42):40778.

Small volumes of anti-I-kappa-Ba (Tyr-305) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472027 is an antibody targeting I-kappa-Ba (Tyr-305). Also known as I-kappa-Ba (Tyr-305), phospho-specific. Reactive in Human, Rat, Mouse. Host: Rabbit.