P130 Cas (Tyr-762) Antibody – Rabbit Polyclonal

p130 Cas (Crk-associated substrate (CAS), breast cancer antiestrogen resistance 1 (BCAR1)) is a docking protein containing multiple protein-protein interaction domains. The amino-terminal SH3 domain may function as a molecular switch regulating CAS tyrosine phosphorylation, as it interacts with focal adhesion kinase (FAK) and the FAK-related kinase PYK2, as well as with the tyrosine phosphatases PTP-1B and PTP-PEST. The carboxy-terminal Src binding domain (SBD) contains a proline-rich motif that mediates interaction with the SH3 domains of Src-family kinases (SFKs) and a tyrosine phosphorylation site (Tyr-762 in rat or Tyr-668 in mouse p130 Cas) that can promote interaction with the SH2 domain of SFKs. The p130 Cas central substrate domain, the major region of tyrosine phosphorylation, is characterized by 15 tyrosines present in Tyr-X-X-Pro (YXXP) motifs, including Tyr-165, Tyr-249, and Tyr-410. When phosphorylated, most YXXP motifs are able to serve as docking sites for proteins with SH2 or PTB domains, including the adaptors Crk and Nck. In addition, phosphorylation of Tyr-751 (Tyr-653 in human) near the C-terminal caspase recognition site can attenuate caspase cleavage. Dephosphorylation of this site occurs during apoptosis, and may facilitate p130 Cas degradation.

• Nakamoto, T. et al. (1996) J Biol Chem. 271 (15):8959.
• Pellicena, P. & Miller, W.T. (2001) J Biol Chem. 276 (30):28190.
• Kim, D.H. et al. (2003) Biochem Biophys Res Comm. 300:141.
• Shin, N.-Y. et al. (2004) J Biol Chem. 279 (37):38331.

Small volumes of anti-p130 Cas (Tyr-762) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472043 is an antibody targeting p130 Cas (Tyr-762). Also known as Anti-p130 Cas (Tyr-762), phospho-specific. Reactive in Human, Rat, Mouse. Host: Rabbit.