Rabbit Anti-SEMA3A Polyclonal Antibody – Cat# MBS472059

Semaphorin-3a (N-Terminal) (SEMA3A) Antibody – Rabbit Polyclonal

Name: SEMA3A Antibody; Polyclonal; Rabbit; Human/Rat/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS472059
Price: 500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS472059

One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI-anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect… More details

$500 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Semaphorin-3A (N-terminal) (SEMA3A), Polyclonal Antibody

Full Product Name

Semaphorin-3A (N-terminal)

Product Gene Name

anti-SEMA3A antibody

Product Synonym Names

Sema3A; Semaphorin III

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Form/Format

Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.

Purity/Purification

Affinity Purified

Specificity

The antibody detects a 95kDa* protein corresponding to the apparent molecular mass of Sema3A on SDS-PAGE immunoblots of human recombinant Sema3A/Fc chimera. This antibody has not been shown to be reactive in neonatal rat brain, but has weak reactivity in adult mouse brain.

Preparation and Storage

Store at -20 degree C. Do not aliquot. Stable for 1 year.

Molecular Weight

86487 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (83587659..83824217, complement). Location: 7p12.1

OMIM

603961

3D Structure

ModBase 3D Structure for Q14563

Immunogen

Semaphorin 3A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the N-terminal region of human Sema3A. The sequence used is identical to similar regions in rat and mouse Sema3A, and has low homology to other semaphorin family members.

Applications Tested/Suitable for anti-SEMA3A antibody

ELISA, Western Blot

Application Notes for anti-SEMA3A antibody

ELISA: 1:2000
Western Blot: 1:1000

Product References and Citations for anti-SEMA3A antibody

• Kolodokin, A.L. et al. (1993) Cell 75:1389.
• Luo, Y. et al. (1993) Cell 75:217.
• Pasterkamp, R.J. & Verhaagen, J. (2001) Brain Res Rev 35:36.

Other Notes

Small volumes of anti-SEMA3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEMA3A purchase

MBS472059 is an antibody targeting SEMA3A. Also known as Semaphorin-3A (N-terminal). Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA3A. It may not necessarily be applicable to this product.

NCBI GI #

5174673

NCBI GeneID

10371

NCBI Accession #

NP_006071.1

UniProt Primary Accession #

Q14563

UniProt Related Accession #

Q14563; Q75MQ2; Q86UJ2

GenBank Nucleotide #

NM_006080.2

NCBI Official Full Name

semaphorin-3A

NCBI Official Synonym Full Names

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

NCBI Official Symbol

SEMA3A

NCBI Official Synonym Symbols

SemD; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; MGC133243

UniProt Protein Name

Semaphorin-3A

UniProt Synonym Protein Names

Semaphorin III

Protein Family

Semaphorin

UniProt Gene Name

SEMA3A

UniProt Synonym Gene Names

SEMAD

UniProt Entry Name

SEM3A_HUMAN

NCBI Protein Information

semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III; OTTHUMP00000161379; OTTHUMP00000208884

NCBI Summary for SEMA3A

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq]

UniProt Comments for SEMA3A

Function: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1

Subcellular location: Secreted

Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similarities: Belongs to the semaphorin family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 PSI domain.Contains 1 Sema domain.

Research Articles on SEMA3A

1. Both systemic and tumor-targeted delivery of SEMA3A inhibits tumor angiogenesis and tumor growth in multiple mouse models; moreover, SEMA3A inhibits the metastatic spreading from primary tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEMA3A antibody

Reference Product	PubMed Publications
NRP1 antibody	>38 publications with SEMA3A and NRP1
SEMA3B antibody	>6 publications with SEMA3A and SEMA3B

Pathways associated with anti-SEMA3A antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
CRMPs In Sema3A Signaling Pathway antibodies	CRMPs In Sema3A Signaling Pathway Diagram
SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies	SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
Sema3A PAK Dependent Axon Repulsion Pathway antibodies	Sema3A PAK Dependent Axon Repulsion Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with anti-SEMA3A antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>49 publications with SEMA3A and Neoplasms
Carcinoma Antibodies	>13 publications with SEMA3A and Carcinoma
Lung Neoplasms Antibodies	>10 publications with SEMA3A and Lung Neoplasms
Adenocarcinoma Antibodies	>9 publications with SEMA3A and Adenocarcinoma
Inflammation Antibodies	>8 publications with SEMA3A and Inflammation
Congenital Abnormalities Antibodies	>7 publications with SEMA3A and Congenital Abnormalities
Breast Neoplasms Antibodies	>6 publications with SEMA3A and Breast Neoplasms
Drug Toxicity Antibodies	>6 publications with SEMA3A and Drug Toxicity
Glioma Antibodies	>5 publications with SEMA3A and Glioma
Heart Defects, Congenital Antibodies	>4 publications with SEMA3A and Heart Defects, Congenital

Organs/Tissues associated with anti-SEMA3A antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>228 publications with SEMA3A and Brain
Embryonic Tissue Antibodies	>133 publications with SEMA3A and Embryonic Tissue
Blood Antibodies	>72 publications with SEMA3A and Blood
Eye Antibodies	>47 publications with SEMA3A and Eye
Muscle Antibodies	>31 publications with SEMA3A and Muscle
Kidney Antibodies	>26 publications with SEMA3A and Kidney
Lung Antibodies	>23 publications with SEMA3A and Lung
Heart Antibodies	>21 publications with SEMA3A and Heart
Skin Antibodies	>15 publications with SEMA3A and Skin
Connective Tissue Antibodies	>10 publications with SEMA3A and Connective Tissue