SHP1 Antibody – Rabbit Polyclonal

SHP1 (PTP1C, SH-PTP1, or HCP) is a protein-tyrosine phosphatase (PTP) involved in cell migration, cell proliferation, and immune cell function. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP1 associates with a variety of cytokine and growth factor receptors and regulates signal transduction through dephosphorylation of these receptors or their downstream effectors. Downstream of receptor activation, SHP1 regulates the transcriptional activity stimulated by JAK/Stat and MAPK pathways. SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr-564 stimulates phosphatase activity and promotes interaction with Grb-2. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity. Thus, phosphorylation at tyrosine relative to serine residues may be regulated by different cell signaling pathways to control SHP1 activity.

• Jones, M.L. et al. (2004) J. Biol. Chem. 279(39):40475.
• Zhang, Z. et al. (2003) J. Biol. Chem. 278(7):4668.
• Zhang, J. et al. (2000) Semin. Immunol. 12:361.
• Simoneau, M. et al. (2008) J Biol Chem Epub:July 10. (WB: S591A transfectants)

Small volumes of anti-SHP1 (Ser-591) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472061 is an antibody targeting SHP1 (Ser-591). Also known as SHP1 (Ser-591), phospho-specific. Reactive in Human, Rat, Mouse. Host: Rabbit.