WAVE Antibody – Rabbit Polyclonal

The Wiskott-Aldrich syndrome protein (WASP) family is involved in various pathways that regulate actin cytoskeletal organization. This family includes WASP, N-WASP, and three WAVE/SCAR isoforms, WAVEs 1, 2, and 3. WAVE proteins play key roles in actin-mediated cell events, such as membrane ruffling and lamellipodia formation. WAVEs contain an Nterminal WAVE homology domain, a basic domain, a Proline-rich region, and carboxy terminal verprolin, cofilin, and acidic (VCA) region. WAVEs are thought to act downstream of the Rac GTPase, connecting Rac activation to induction of Arp 2/3-mediated actin polymerization. Regulation of WAVE activity can occur through tyrosine phosphorylation. Src phosphorylation of WAVE1 at Tyr-125 enhances binding to the Arp2/3 complex, and is required for WAVE inhibition of Arp2/3-mediated stress fiber formation. By contrast, WAVE2 phosphorylation of Tyr-150 by Abl may enhance Arp2/3 complex actin nucleation and microspike formation in fibroblasts. Thus, site-specific tyrosine phosphorylation may be important for controlling specific activities of WAVE proteins.

• Ardern, H. et al. (2006) Cell Motil. Cytosk. 63:6
• Leng, Y. et al. (2005) PNAS 102(4):1098
• Suetsugu, S. et al. (1999) Bioch. Biophs. Res. Comm. 260:296
• Miki, H. et al. (1999) J Biol. Chem. 274(39):27605

Small volumes of anti-WAVE (Tyr-125) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS472067 is an antibody targeting WAVE (Tyr-125). Also known as WAVE (Tyr-125), phospho-specific. Reactive in Human, Rat, Mouse. Host: Rabbit.