Rabbit Anti-DISC1 Polyclonal Antibody – Cat# MBS474096

Western blot of DISC1 in mouse brain (lanes 1 & 3) and rat PC12 cells (lanes 2 & 4). The blots were probed with DP3021 anti-DISC1 (a.a. 740-753) (lanes 1 & 2) and DP3041 anti-DISC1 (a.a. 740-753) (lanes 3 & 4).

DISC1 Antibody – Rabbit Polyclonal

Name: DISC1 Antibody; Polyclonal; Rabbit; Rat/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS474096
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS474096

Disrupted in schizophrenia 1 (DISC1) is a multifunctional scaffold protein that has important roles in neurodevelopment. DISC1 is expressed in both neuronal progenitor cells and postmitotic neurons in the developing cerebral cortex. DISC1 can interact with… More details

$435 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DISC1, Polyclonal Antibody

Full Product Name

DISC1 (a.a. 740-753)

Product Gene Name

anti-DISC1 antibody

Product Synonym Names

disrupted schizophrenia

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Rat, Mouse

Form/Format

Supplied in 100ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.

Purity/Purification

Affinity Purified

Specificity

This antibody was affinity purified using DISC1 (a.a. 740-753) peptide (without carrier). The antibody detects a 100 kDa* protein corresponding to the molecular mass of DISC1 on SDS-PAGE immunoblots of mouse brain and rat PC12 cells.

Preparation and Storage

Store at -20 degree C. Stable for 1 year.

Molecular Weight

100 kDa

3D Structure

ModBase 3D Structure for Q811T9

Immunogen

DISC1 synthetic peptide (coupled to KLH) containing amino acid residues 740 to 753 from mouse DISC1. This peptide sequence is well conserved in rat DISC1, but has 7 amino acid differences with the conserved site in human DISC1.

Applications Tested/Suitable for anti-DISC1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-DISC1 antibody

ELISA: 1:1000
WB: 1:500
WB: Western blot membranes were incubated with diluted antibody in 5% non-fat milk, PBS, 0.04% Tween20 for 1 hour at room temperature.

Product References and Citations for anti-DISC1 antibody

Mao, Y. et al. (2009) Cell. 136(6):1017.Brandon, N.J. et al. (2011) Nat Rev Neurosci. 12(12):707.Ishizuka, K. (2011) Nature. 473(7345):92.

Other Notes

Small volumes of anti-DISC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DISC1 purchase

MBS474096 is an antibody targeting DISC1. Also known as DISC1 (a.a. 740-753). Reactive in Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DISC1. It may not necessarily be applicable to this product.

NCBI GI #

119874423

NCBI GeneID

244667

NCBI Accession #

NP_777278.2

UniProt Primary Accession #

Q811T9

UniProt Related Accession #

Q811T9

GenBank Nucleotide #

NM_174853.2

NCBI Official Full Name

disrupted in schizophrenia 1 homolog isoform 2

NCBI Official Synonym Full Names

disrupted in schizophrenia 1

NCBI Official Symbol

Disc1

UniProt Protein Name

Disrupted in schizophrenia 1 homolog

Protein Family

Disrupted in schizophrenia

UniProt Gene Name

Disc1

UniProt Entry Name

DISC1_MOUSE

NCBI Protein Information

disrupted in schizophrenia 1 homolog

Research Articles on DISC1

1. Chronic pre-pregnancy stress can induce dams into postpartum depression. The pathogenesis of postpartum depression may be related to the regulation of DISC1 in the hippocampus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DISC1 antibody

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>361 publications with DISC1 and Schizophrenia
Syndrome Antibodies	>21 publications with DISC1 and Syndrome
Autistic Disorder Antibodies	>7 publications with DISC1 and Autistic Disorder
Asperger Syndrome Antibodies	>5 publications with DISC1 and Asperger Syndrome
Schizophrenia, Childhood Antibodies	>4 publications with DISC1 and Schizophrenia, Childhood
Prenatal Exposure Delayed Effects Antibodies	>3 publications with DISC1 and Prenatal Exposure Delayed Effects
Intellectual Disability Antibodies	>2 publications with DISC1 and Intellectual Disability
Aneuploidy Antibodies	>2 publications with DISC1 and Aneuploidy
Chromosome Breakage Antibodies	>2 publications with DISC1 and Chromosome Breakage
Mitochondrial Diseases Antibodies	>2 publications with DISC1 and Mitochondrial Diseases

Organs/Tissues associated with anti-DISC1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>216 publications with DISC1 and Brain