Semaphorin-6a (SEMA6A) Antibody – Rabbit Polyclonal

The Semaphorin family of axon guidance molecules includes secreted, transmembrane, and GPI-anchored extracellular molecules that have been implicated in neuron development, vascular disease, and tumor progression. There are eight classes of semaphorin genes, all of which are characterized by a conserved 500 amino acid, cystine-rich Sema domain. Semaphorin 6A (Sema-6A) is a single-pass type I membrane protein that contains a plexin-semaphorin-integrin (PSI) domain and a Sema domain. Sema-6A is active as a homodimer or oligomer. The Sema-6A homodimer interacts with a Plexin A2 homodimer. Sema-6a promotes reorganization of the actin cytoskeleton to regulate normal granule cell migration in the developing cerebellum and to control axon guidance in the developing central nervous system. In addition, Sema-6a has been implicated in oligodendrocyte myelination and may alter VEGF signaling during angiogenesis.

Xu, X.M. (2000) J Neurosci. 20(7):2638.Bernard, F. et al. (2012) Glia. 60(10):1590. Segarra, M. et al. (2012) Blood. 120(19):4104.

Small volumes of anti-SEMA6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS474144 is an antibody targeting SEMA6A. Also known as Semaphorin-6A (C-terminus). Reactive in Human, Rat, Mouse, Chicken. Host: Rabbit.