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Annexin A2 (A2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS474162

The Annexin family of is composed of al least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer… More details

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Product Overview

Online Datasheet in PDF
Product Name
Annexin A2, Monoclonal Antibody
Full Product Name
Annexin A2 Antibody
Product Gene Name
anti-A2 antibody
Product Synonym Names
Annexin A2; Annexin A2 M009
Clonality
Monoclonal
Isotype
IgG1
Clone Number
M009
Host
Mouse
Species Reactivity
Human
Form/Format
Mouse monoclonal, protein G purified antibody is supplied in 100ul phosphate-buffered saline, 50% glycerol, 1mg/ml BSA, and 0.05% sodium azide.
Specificity
Clone M009 detects a 36kDa* protein corresponding to the molecular mass of Annexin A2 on SDS-PAGE immunoblots of human A431, MDA-MB-231, MeWo, HUVEC, and PC3 cells. The antibody also works for ELISA, immunocytochemical labeling, and immunoprecipitation applications. In addition, mass spectrometry analysis of immunoprecipitates using AM0091 in human A431 cell lysates confirms that this antibody only detects Annexin A2 protein.
Preparation and Storage
Store at -20 degree C. Stable for 1 year.
Molecular Weight
38,893 Da
3D Structure
ModBase 3D Structure for Q07936
Immunogen
Clone M009 was generated from a proprietary antigen related to human Annexin A2 in MDA-MB-231 breast cancer cell line.
Applications Tested/Suitable for anti-A2 antibody
Western Blot (WB), Immunocytochemistry (ICC), ELISA (EIA), Immunoprecipitation-Mass Spectrometry (IP-MS)
Application Notes for anti-A2 antibody
ELISA: 1:1000
ICC: 1:100
IP-MS: 1:100
WB: 1:1000

Western Blot (WB) of anti-A2 antibody

Western blot of human A431 (lane 1), MDA-MB-231 (lane 2), LNCaP (lane 3), MeWo (lane 4), HUVEC (lane 5), Jurkat (lane 6), K562 (lane 7), and PC3 (lane 8) cell lysates. The blot was probed with mouse monoclonal anti-Annexin A2 antibody (AM0091) at 1:500 (lanes 1-8).
Mouse Anti-A2 Monoclonal Antibody – Cat# MBS474162

Product References and Citations for anti-A2 antibody

Grewal, T. & Enrich, C. (2006) Bioessays 28(12):1211.
Feinberg, J.M. et al. (1991) J Histochem & Cytochem. 39:955.

Other Notes

Small volumes of anti-A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A2 purchase

MBS474162 is an antibody targeting A2. Also known as Annexin A2 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for A2. It may not necessarily be applicable to this product.

NCBI GI #
9845234
NCBI GeneID
56611
NCBI Accession #
NP_063970.1
UniProt Primary Accession #
Q07936
UniProt Related Accession #
Q07936
GenBank Nucleotide #
NM_019905.1
NCBI Official Full Name
annexin A2
NCBI Official Synonym Full Names
annexin A2
NCBI Official Symbol
Anxa2
NCBI Official Synonym Symbols
ANX2
UniProt Protein Name
Annexin A2
UniProt Synonym Protein Names
Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
Protein Family
Protein
UniProt Gene Name
Anxa2
UniProt Synonym Gene Names
Anx2; PAP-IV
NCBI Protein Information
annexin A2

NCBI Summary for A2

a plasminogen receptor; may be involved in cellular transformation [RGD, Feb 2006]

UniProt Comments for A2

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
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Research Articles on A2

1. Oxidative stress causes the incorporation of pTyr23AnxA2 into extracellular vesicles.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-A2 antibody

 Reference Product  PubMed Publications
 S100a10 antibody  >152 publications with A2 and S100a10
 S100a6 antibody  >20 publications with A2 and S100a6
 S100a4 antibody  >17 publications with A2 and S100a4
 Plg antibody  >13 publications with A2 and Plg
 Cdc42 antibody  >8 publications with A2 and Cdc42
 Pcsk9 antibody  >5 publications with A2 and Pcsk9
 Tp53 antibody  >4 publications with A2 and Tp53
 Ptpn11 antibody  >1 publications with A2 and Ptpn11
 Hsp90ab1 antibody  >1 publications with A2 and Hsp90ab1

Pathways associated with anti-A2 antibody

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram

Diseases associated with anti-A2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >120 publications with A2 and Inflammation
 Neoplasm Metastasis Antibodies  >87 publications with A2 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >79 publications with A2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >71 publications with A2 and Disease Models, Animal
 Neoplasm Invasiveness Antibodies  >58 publications with A2 and Neoplasm Invasiveness
 Liver Diseases Antibodies  >58 publications with A2 and Liver Diseases
 Necrosis Antibodies  >55 publications with A2 and Necrosis
 Carcinoma, Squamous Cell Antibodies  >46 publications with A2 and Carcinoma, Squamous Cell
 Carcinoma, Hepatocellular Antibodies  >44 publications with A2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >43 publications with A2 and Liver Neoplasms

Organs/Tissues associated with anti-A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >122 publications with A2 and Lung
 Brain Antibodies  >120 publications with A2 and Brain
 Liver Antibodies  >104 publications with A2 and Liver
 Kidney Antibodies  >78 publications with A2 and Kidney
 Embryonic Tissue Antibodies  >53 publications with A2 and Embryonic Tissue
 Artery Antibodies  >42 publications with A2 and Artery
 Placenta Antibodies  >38 publications with A2 and Placenta
 Prostate Antibodies  >35 publications with A2 and Prostate
 Colon Antibodies  >34 publications with A2 and Colon
 Heart Antibodies  >33 publications with A2 and Heart
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