CHD4 Antibody – Mouse Monoclonal

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

CHD-4: is an ATP-dependent helicase and a central component of the HDAC-containing nucleosome remodeling and histone deacetylase (NuRD) transcriptional complex. Interacts with MTA1/2, HDAC1, and RbAp46 in the NuRD complex. CHD-4 belongs to the SNF2/RAD54 helicase family of proteins. The NuRD complex, whose subunit composition varies by cell type and in response to physiologic signals, plays central roles in many processes including oncogenesis and metastasis, B cell differentiation, invasive growth of breast cancer, and maintaining the balance between the undifferentiated state and the process of differentiation in embryonic stem cells.

Protein type: DNA-binding; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: centrosome; cytoplasm; membrane; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex

Molecular Function: ATP-dependent DNA helicase activity; DNA binding; histone deacetylase activity; histone deacetylase binding; nucleosomal DNA binding; protein binding

Biological Process: ATP-dependent chromatin remodeling; regulation of transcription from RNA polymerase II promoter

Disease: Sifrim-hitz-weiss Syndrome